Animal bioscience · 2026
Dietary supplementation of cysteamine promotes Hu lamb growth performance via somatotropic axis potentiation.
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Li QinWu, Xie Tongtong, Wang Xuan, Li Fadi, Li Fei, Guo Tao, Guo Long
Аннотация
OBJECTIVES: Cysteamine (CS) is known for its ability to regulate hormone secretion. Although widely used as a growth promoter for ruminants, long-term administration at high doses causes intestinal ulceration and growth retardation. We have previously demonstrated that long-term supplementing 20 mg CS/kg BW does not affect growth performance.
METHODS: This study aimed to elucidate the impacts of 30 mg CS kg⁻¹ BW administered for 30 days on growth performance, hormonal profiles, rumen fermentation parameters, rumen bacterial communities, and muscle characteristics in Hu lambs. This dosage and duration regimen demonstrated efficacy in promoting growth performance while avoiding the ruminal adverse effects observed at higher doses. Thirty-six male Hu lambs were randomly assigned to two groups.
RESULTS: The CS supplementation exhibited higher final body weight, average daily gain (ADG), and dry matter intake (DMI) during the first 21 days of the experimental period (p < 0.05). Hormonal analysis revealed that CS supplementation increased the levels of growth hormone (GH), luteinizing hormone (LH) in the pituitary, testosterone (T) in the testis, and IGF-I in the serum, while decreasing the levels of somatostatin (SS) in the hypothalamus and serum (p < 0.05). Rumen fermentation analysis indicated an increase in total volatile fatty acids (VFAs) and the proportion of valerate (p < 0.05), while the proportion of acetate and the acetate/propionate ratio decreased (p < 0.05). Muscle analysis revealed decreased mRNA expression levels of MyHCIIb (p < 0.05) in the longissimus dorsi muscle. Western blot analysis demonstrated increased expression of mTOR proteins, along with elevated phosphorylation level of mTOR (p < 0.05) in the longissimus dorsi muscle.
CONCLUSION: Collectively, this study demonstrates that dietary CS supplementation enhances growth performance in Hu lambs by improving rumen function and modulating somatotropic axis hormones.
METHODS: This study aimed to elucidate the impacts of 30 mg CS kg⁻¹ BW administered for 30 days on growth performance, hormonal profiles, rumen fermentation parameters, rumen bacterial communities, and muscle characteristics in Hu lambs. This dosage and duration regimen demonstrated efficacy in promoting growth performance while avoiding the ruminal adverse effects observed at higher doses. Thirty-six male Hu lambs were randomly assigned to two groups.
RESULTS: The CS supplementation exhibited higher final body weight, average daily gain (ADG), and dry matter intake (DMI) during the first 21 days of the experimental period (p < 0.05). Hormonal analysis revealed that CS supplementation increased the levels of growth hormone (GH), luteinizing hormone (LH) in the pituitary, testosterone (T) in the testis, and IGF-I in the serum, while decreasing the levels of somatostatin (SS) in the hypothalamus and serum (p < 0.05). Rumen fermentation analysis indicated an increase in total volatile fatty acids (VFAs) and the proportion of valerate (p < 0.05), while the proportion of acetate and the acetate/propionate ratio decreased (p < 0.05). Muscle analysis revealed decreased mRNA expression levels of MyHCIIb (p < 0.05) in the longissimus dorsi muscle. Western blot analysis demonstrated increased expression of mTOR proteins, along with elevated phosphorylation level of mTOR (p < 0.05) in the longissimus dorsi muscle.
CONCLUSION: Collectively, this study demonstrates that dietary CS supplementation enhances growth performance in Hu lambs by improving rumen function and modulating somatotropic axis hormones.