European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
Metachronous nasopharyngeal carcinoma following sinonasal inverted papilloma - a diagnostic enigma.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Dosemane Deviprasad, Khadilkar Meera Niranjan, Chandy Nithya, Subramanian Divya, Rao Nayana, Iqbal Susana
Аннотация
BACKGROUND: Inverted papilloma (IP) is a benign Schneiderian epithelial tumour with a well-recognized potential for recurrence and malignant transformation, most commonly to squamous cell carcinoma (SCC). Carcinoma arising in the nasopharynx after prior IP is exceedingly rare, and distinguishing malignant conversion from a metachronous nasopharyngeal carcinoma (NPC) poses a diagnostic challenge. CASE REPORT: We report a rare, interesting case of a nasopharyngeal lesion with histopathological features of non-keratinizing SCC in a patient previously treated surgically for sinonasal IP. CONCLUSION: Differentiating malignant transformation of IP from a metachronous malignancy is complex. In this case, the short interval between diagnoses, anatomical separation, and absence of Schneiderian features favour interpretation as a metachronous NPC, highlighting the importance of continued surveillance and prompt evaluation of new symptoms in patients treated for IP.