MedElevator
Войти в исследования Oral diseases · 2026
Extracellular Matrix Remodeling in Actinic Cheilitis and Lip Squamous Cell Carcinoma: A Cross-Sectional Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Alfaia-Silva Caroline, de Farias Polyane Caroline Arruda, de Mello da Silva Fernanda, de Paula Ribeiro Lidiane, de Paiva Vieira Ericles, Rivero Elena Riet Correa, Modolo Filipe
Аннотация
BACKGROUND: Actinic cheilitis is a precursor to lip squamous cell carcinoma. How ultraviolet-induced stromal degeneration relates to invasion-related extracellular matrix markers remains unclear. This study investigated basophilic degeneration of collagen, solar elastosis, fibronectin, tenascin-C, and podoplanin in both lesions.
METHODS: Specimens of actinic cheilitis (n = 28) and lip squamous cell carcinoma (n = 28) were analyzed. Collagen degeneration, elastosis, and the immunoexpression of fibronectin, tenascin-C, and podoplanin were quantified using digital image analysis. Associations were evaluated using mixed-effects models.
RESULTS: Collagen degeneration and elastosis areas were significantly greater in actinic cheilitis (p < 0.001). Lip squamous cell carcinoma exhibited higher stromal fibronectin and podoplanin (p < 0.001), whereas epithelial tenascin-C was higher in actinic cheilitis (p < 0.001). Notably, in both lesions, areas with pronounced collagen degeneration and elastosis were inversely associated with the expression of these invasion-related proteins.
CONCLUSIONS: Actinic cheilitis features marked actinic stromal degeneration, whereas lip squamous cell carcinoma exhibits tumor-driven extracellular matrix remodeling with increased invasion-related markers. These findings highlight distinct stromal microenvironment profiles associated with pre-neoplastic and neoplastic lip lesions.
METHODS: Specimens of actinic cheilitis (n = 28) and lip squamous cell carcinoma (n = 28) were analyzed. Collagen degeneration, elastosis, and the immunoexpression of fibronectin, tenascin-C, and podoplanin were quantified using digital image analysis. Associations were evaluated using mixed-effects models.
RESULTS: Collagen degeneration and elastosis areas were significantly greater in actinic cheilitis (p < 0.001). Lip squamous cell carcinoma exhibited higher stromal fibronectin and podoplanin (p < 0.001), whereas epithelial tenascin-C was higher in actinic cheilitis (p < 0.001). Notably, in both lesions, areas with pronounced collagen degeneration and elastosis were inversely associated with the expression of these invasion-related proteins.
CONCLUSIONS: Actinic cheilitis features marked actinic stromal degeneration, whereas lip squamous cell carcinoma exhibits tumor-driven extracellular matrix remodeling with increased invasion-related markers. These findings highlight distinct stromal microenvironment profiles associated with pre-neoplastic and neoplastic lip lesions.