Redefining Radiotherapy: The Gut as an Active Target in Immuno-oncology.

Low-dose intestinal irradiation challenges the long-standing view of the gut as a radiation-sensitive organ to avoid. Clinical and mechanistic data suggest that targeted exposure of the small intestine within a 1- to 3-Gy window can remodel the microbiome and enhance systemic antitumor immunity. See related article by Huang et al., p. 3586.