Immunotherapy · 2024
Patterns of neurological adverse events among a retrospective cohort of patients receiving immune checkpoint inhibitors.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Hunting John C, Faucheux Andrew T, Price Sarah N, Elko Catherine A, Quattlebaum Alexander, Bloomer Chance, Olson Eric, Petty William J, Lycan Thomas W
Аннотация
Aim: Neurological adverse events (NAEs) are infrequent immune checkpoint inhibitor (ICI) outcomes poorly characterized in extant research, complicating their clinical management. Methods: This study characterized the frequency, severity, patterning and timing of NAEs using a large retrospective registry, including all patients who received at least one dose of an ICI from 2/1/2011-4/7/2022 within our health network. Results: Among 3137 patients, there were 54 NAEs (1.72% any grade; 0.8% grade 3-4). Most NAEs were peripheral (57.4%) versus central (42.6%). Melanoma and renal cell carcinoma were significantly associated with NAEs. Conclusion: The incidence of NAEs was rare though higher than many prior case estimates; the timing was consistent with other AEs. NAEs frequently occurred in tumor types known to favor brain metastases.