Acta oto-laryngologica · 2025
Squamous cell carcinoma variants in the major salivary glands: a population-based study.
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Sudo Tomoyuki, Tojima Ichiro, Yamazaki Kai, Nishiguchi Tatsuji, Kubo Yoshihito, Kawakita Kento, Matsumoto Koji, Owaki Shigehiro, Takenaka Yukinori
Аннотация
BACKGROUND: Primary squamous cell carcinoma (SCC) of the major salivary glands is a rare malignancy with poor prognosis. Histological variants may differ in clinical presentation and outcomes.
OBJECTIVES: To clarify the clinicopathological features and prognostic impact of SCC variants in the major salivary glands using a large population-based dataset.
PATIENTS AND METHODS: We analysed 3581 patients with primary salivary gland SCC. Variants included conventional SCC, lymphoepithelial carcinoma (LEC), basaloid SCC (BSCC), and spindle cell carcinoma (SpCC). Overall survival (OS) and disease-specific survival (DSS) were evaluated by the Kaplan-Meier method and Cox regression analyses.
RESULTS: Conventional SCC accounted for 92.7% of cases, followed by LEC (3.7%), BSCC (1.7%), and SpCC (1.3%). The 5-year OS rates were 39.0% for conventional SCC, 76.4% for LEC, 51.5% for BSCC, and 41.8% for SpCC (p < 0.001). The corresponding DSS rates were 60.0%, 85.6%, 62.7%, and 64.9% (p < 0.001). In multivariate analysis, LEC was independently associated with superior survival, with hazard ratios of 0.50 (95% confidence interval (CI) 0.36-0.71) for OS and 0.46 (95% CI 0.28-0.74) for DSS, whereas BSCC and SpCC showed outcomes comparable to conventional SCC.
CONCLUSIONS: Histological variant is a significant prognostic factor in salivary gland SCC. LEC showed favourable survival.
OBJECTIVES: To clarify the clinicopathological features and prognostic impact of SCC variants in the major salivary glands using a large population-based dataset.
PATIENTS AND METHODS: We analysed 3581 patients with primary salivary gland SCC. Variants included conventional SCC, lymphoepithelial carcinoma (LEC), basaloid SCC (BSCC), and spindle cell carcinoma (SpCC). Overall survival (OS) and disease-specific survival (DSS) were evaluated by the Kaplan-Meier method and Cox regression analyses.
RESULTS: Conventional SCC accounted for 92.7% of cases, followed by LEC (3.7%), BSCC (1.7%), and SpCC (1.3%). The 5-year OS rates were 39.0% for conventional SCC, 76.4% for LEC, 51.5% for BSCC, and 41.8% for SpCC (p < 0.001). The corresponding DSS rates were 60.0%, 85.6%, 62.7%, and 64.9% (p < 0.001). In multivariate analysis, LEC was independently associated with superior survival, with hazard ratios of 0.50 (95% confidence interval (CI) 0.36-0.71) for OS and 0.46 (95% CI 0.28-0.74) for DSS, whereas BSCC and SpCC showed outcomes comparable to conventional SCC.
CONCLUSIONS: Histological variant is a significant prognostic factor in salivary gland SCC. LEC showed favourable survival.