The British journal of dermatology · 2014
Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Guenova E, Schanz S, Hoetzenecker W, DeSimone J A, Mehra T, Voykov B, Urosevic-Maiwald M, Berneburg M, Dummer R, French L E, Kerl K, Kamarashev J, Fierlbeck G, Cozzio A
Аннотация
BACKGROUND: Primary cutaneous γ/δ T-cell lymphoma (PCGD-TCL) is aggressive and has a poor prognosis. In contrast, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) of the α/β T-cell receptor phenotype is known to follow an indolent course and have a more favourable prognosis. In the past, PCGD-TCL and SPTCL were often considered to be a manifestation of the same disease, and aggressive systemic polychemotherapy has commonly been the first-line therapy for both. Given the understanding that SPTCL is a separate and less aggressive entity, clinical data exclusively evaluating the efficacy of conservative treatment in SPTCL are needed.
OBJECTIVES: To assess the overall clinical response to systemic corticosteroids in the treatment of SPTCL.
METHODS: This was a retrospective cross-sectional study based on a patient data repository from two tertiary care university hospitals in Zürich (Switzerland) and Tübingen (Germany). The repository spanned 13 years.
RESULTS: In four of the five patients (80%) with SPTCL, treatment with systemic corticosteroids induced a complete remission.
CONCLUSIONS: Systemic corticosteroids may be an excellent first-line single-agent therapy for SPTCL.
OBJECTIVES: To assess the overall clinical response to systemic corticosteroids in the treatment of SPTCL.
METHODS: This was a retrospective cross-sectional study based on a patient data repository from two tertiary care university hospitals in Zürich (Switzerland) and Tübingen (Germany). The repository spanned 13 years.
RESULTS: In four of the five patients (80%) with SPTCL, treatment with systemic corticosteroids induced a complete remission.
CONCLUSIONS: Systemic corticosteroids may be an excellent first-line single-agent therapy for SPTCL.