Surgery today · 2026
Early drain fluid lymphocyte fraction as a predictor of postoperative infectious complications after hepatectomy.
СтатьяНазвание и аннотация: Перевод в очереди
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Furukawa Kenei, Tsunematsu Masashi, Haruki Koichiro, Shirai Yoshihiro, Matsumoto Michinori, Onda Shinji, Akaoka Munetoshi, Taniai Tomohiko, Yanagaki Mitsuru, Ikegami Toru
Аннотация
PURPOSE: Postoperative infectious complications remain one of the most common morbidities after hepatectomy. We conducted this study to evaluate whether the lymphocyte fraction in drain fluid could serve as a surrogate marker of postoperative infectious complications after hepatectomy.
METHODS: The subjects of this retrospective analysis were 265 patients who underwent hepatectomy. Drain fluid samples were collected on postoperative day (POD) 1, for biochemical and hematologic evaluation. The associations between the lymphocyte fraction in drain fluid and postoperative infectious complications were examined using univariate and multivariate logistic regression analyses.
RESULTS: Postoperative infectious complications developed in 43 patients (16%). Multivariate analysis identified biliary reconstruction (odds ratio (OR) 4.20, p = 0.02), total bilirubin concentration in drain fluid ≥ 1.0 mg/dL (OR 3.32, p < 0.01), and lymphocyte fraction in drain fluid < 0.7% (OR 4.09, p < 0.01) as independent risk factors. No correlation was found between peripheral blood and drain fluid lymphocyte fractions (r = 0.02, p = 0.77).
CONCLUSION: A reduced lymphocyte fraction in drain fluid on POD1 is an independent predictor of postoperative infectious complications after hepatectomy and may reflect the postoperative local immune environment rather than systemic immunity.
METHODS: The subjects of this retrospective analysis were 265 patients who underwent hepatectomy. Drain fluid samples were collected on postoperative day (POD) 1, for biochemical and hematologic evaluation. The associations between the lymphocyte fraction in drain fluid and postoperative infectious complications were examined using univariate and multivariate logistic regression analyses.
RESULTS: Postoperative infectious complications developed in 43 patients (16%). Multivariate analysis identified biliary reconstruction (odds ratio (OR) 4.20, p = 0.02), total bilirubin concentration in drain fluid ≥ 1.0 mg/dL (OR 3.32, p < 0.01), and lymphocyte fraction in drain fluid < 0.7% (OR 4.09, p < 0.01) as independent risk factors. No correlation was found between peripheral blood and drain fluid lymphocyte fractions (r = 0.02, p = 0.77).
CONCLUSION: A reduced lymphocyte fraction in drain fluid on POD1 is an independent predictor of postoperative infectious complications after hepatectomy and may reflect the postoperative local immune environment rather than systemic immunity.