Hematology (Amsterdam, Netherlands) · 2023
A phase II study of lenalidomide and rituximab (R2) combination in patients with high-risk refractory/relapsed diffuse large B-cell lymphoma.
Клиническое исследование II фазыСтатьяНазвание и аннотация: Перевод в очереди
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Noel Robin, Zemmour Christophe, Montes de Oca Catalina, Belmecheri Nawel, Aurran-Schleinitz Thérèse, Coso Diane, Lopez Almeida Leonor, Mescam Lénaïg, Vey Norbert, Bladé Jean Sébastien, Slama Borhane, Bouabdallah Reda, Schiano de Colella Jean-Marc
Аннотация
Relapsed/Refractory Diffuse Large B Cell Lymphoma have a dismal prognosis in need of innovative treatments. This prospective phase 2 study enrolled 32 patients between 2013 and 2017 with Relapsed/Refractory Diffuse Large B Cell Lymphoma treated with Rituximab and Lenalidomide (R2). Median age was 69 years (40-86), 90.1% had received at least 2 prior lines of treatment, 81% were defined as having High Risk disease according to our criteria and ECOG performance status was > 2 in 51.6%. Patients received a median number of 2 cycles of R2 (1-12). With a median follow up of 22.6 months, the objective response rate was 12.5%. Median progression free survival was 2.6 months (95% CI, [1.7-2.9]) and median overall survival was 9.3 months (95% CI, [5.1-Not estimable]). This study therefore did not achieve its primary endpoint and the R2 regimen cannot be recommended in Relapsed/Refractory Diffuse Large B Cell Lymphoma patients with High Risk features.