Pancreas · 2026
rs928508 of miR-30c-5p is Associated With the Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.
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Sun Yunyun, Li Xia, Chen Liang, Zhang Jun
Аннотация
OBJECTIVE: Endoscopic retrograde cholangiopancreatography (ERCP) is a widely utilized endoscopic technique for the diagnosis and therapy of biliary and pancreatic diseases. It usually leads to different complications including post-ERCP pancreatitis (PEP). This study aimed to evaluate the correlation between miR-30c-5p rs928508 polymorphism and the risk of PEP and to analyze the effect of it on serum miR-30c-5p level.
MATERIALS AND METHODS: Patients with PEP were collected as a case group, while patients without complications were gathered as a control group. miR-30c-5p levels were measured using qRT-PCR, and rs928508 genotyping was performed using the TaqMan method. Logistic regression analysis was used to recognize independent risk factors for PEP.
RESULTS: The case group had significantly lower miR-30c-5p levels, especially in AG/GG genotype carriers. rs928508 was correlated with increased PEP risk under GG versus AA (OR = 2.170, 95% CI = 1.118-4.210), AG/GG versus AA ( P = 0.032, OR = 1.840, 95% CI = 1.048-3.231) and G versus A ( P = 0.026, OR = 1.433, 95% CI = 1.043-1.969) models. Meanwhile, AG (OR = 33.023, 95% CI = 1.026-8.906), GG (OR = 3.344, 95% CI = 1.070-10.450), and AG/GG (OR = 3.138, 95% CI = 1.103-8.932) genotypes were correlated with high severity of PEP. Multivariate analysis suggested that drinking (OR = 2.091, 95% CI = 1.102-3.968), difficult cannulation (OR = 2.198, 95% CI = 1.301-3.712), pancreatic duct visualization (OR = 5.468, 95% CI = 2.945-10.151), pancreatic duct stenting history (OR = 3.415, 95% CI = 1.742-6.693), and AG/GG genotypes of rs928508 (OR = 2.137, 95% CI = 1.114-4.100) were independent risk factors for PEP onset.
CONCLUSION: miR-30c-5p rs928508 polymorphism is correlated with an enhanced risk and severity of PEP.
MATERIALS AND METHODS: Patients with PEP were collected as a case group, while patients without complications were gathered as a control group. miR-30c-5p levels were measured using qRT-PCR, and rs928508 genotyping was performed using the TaqMan method. Logistic regression analysis was used to recognize independent risk factors for PEP.
RESULTS: The case group had significantly lower miR-30c-5p levels, especially in AG/GG genotype carriers. rs928508 was correlated with increased PEP risk under GG versus AA (OR = 2.170, 95% CI = 1.118-4.210), AG/GG versus AA ( P = 0.032, OR = 1.840, 95% CI = 1.048-3.231) and G versus A ( P = 0.026, OR = 1.433, 95% CI = 1.043-1.969) models. Meanwhile, AG (OR = 33.023, 95% CI = 1.026-8.906), GG (OR = 3.344, 95% CI = 1.070-10.450), and AG/GG (OR = 3.138, 95% CI = 1.103-8.932) genotypes were correlated with high severity of PEP. Multivariate analysis suggested that drinking (OR = 2.091, 95% CI = 1.102-3.968), difficult cannulation (OR = 2.198, 95% CI = 1.301-3.712), pancreatic duct visualization (OR = 5.468, 95% CI = 2.945-10.151), pancreatic duct stenting history (OR = 3.415, 95% CI = 1.742-6.693), and AG/GG genotypes of rs928508 (OR = 2.137, 95% CI = 1.114-4.100) were independent risk factors for PEP onset.
CONCLUSION: miR-30c-5p rs928508 polymorphism is correlated with an enhanced risk and severity of PEP.