Esophageal carcinosarcoma: A rare case report.

INTRODUCTION

Esophageal carcinosarcoma (ECS) is a rare malignant tumor with a polypoid configuration. It is biphasic and composed of epithelial carcinomatous and mesenchymal sarcomatous components.

CASE PRESENTATION: We present a 74-year-old Persian woman with a known case of hypertension and chronic renal insufficiency who presented with dysphagia one month ago. On presentation she was oriented, with normal ranged Vital signs. The vital signs were within normal ranges. Her physical examination revealed pale conjunctiva. Gastrointestinal endoscopy showed a 29*25 mm ulcerative polypoid lesion in the distal part of the esophagus which several biopsies were taken. Microscopic examination revealed biphasic mesenchymal and epithelial malignant tumors compatible with carcinosarcoma.

DISCUSSION: Dysphagia is the most common symptom of ECS. Immunohistochemistry is the diagnostic gold standard for ECS. The markers for the carcinomatous elements are CEA, EMA, pancreatin, chromogranin A, CD56, and synaptophysin, and for the sarcomatous elements, desmin, p63, vimentin, and smooth muscle/sarcomeric actin.

CONCLUSION

ECS is a biphasic tumor and the most effective treatment option for ECS is surgical resection.