Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013
High-dose chemotherapy and autologous stem cell transplantation for nodular lymphocyte-predominant Hodgkin lymphoma.
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Karuturi Meghan, Hosing Chitra, Fanale Michelle, Medeiros L Jeffrey, Alousi Amin M, de Lima Marcos J, Qazilbash Muzaffar H, Kebriaei Partow, Younes Anas, Khouri Issa, Andersson Borje S, Champlin Richard, Anderlini Paolo, Popat Uday
Аннотация
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a distinct subtype of Hodgkin lymphoma that is characterized by unique clinical presentation, histological appearance, and indolent disease course. The recurrent nature of disease provides an opportunity to examine the role of stem cell transplantation in its management. We report here a single-center experience of 26 patients with relapsed NLPHL treated with high-dose chemotherapy and autologous stem cell transplantation between 1990 and 2008. With a median follow-up of 50 months (range, 2-138 months), the 5-year overall and event-free survival were 76% (SE 10%) and 69% (SE 10%), respectively. Our data suggest that high-dose chemotherapy and autologous transplantation should be considered as an option for patients with relapsed NLPHL.