Current eye research · 2026
Corneal Sensitivity, Sub-Basal Corneal Nerve Plexus, and Tear Neuropeptides in Symptomatic Versus Asymptomatic Visual Display Terminal Users.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Maity Moumi, Siddiqui Mohammad Gufran, Singh Vivek, Basu Sayan, Singh Swati
Аннотация
PURPOSE: The current study evaluated the structure and function of corneal nerves in symptomatic versus asymptomatic visual display terminal (VDT) users, along with tear neuropeptides.
METHODS: A cross-sectional, single-masked study divided VDT users into symptomatic (n = 51; ocular surface disease index (OSDI) > 13, tear osmolarity, noninvasive tear break-up time (NIBUT) < 10 s, and positive corneal staining) and asymptomatic groups (n = 21, OSDI ≤ 13, NIBUT > 10 s). Participants underwent detailed tear film examination (Oculus keratograph 5M), blink rate, corneal sensitivity (Cochet-Bonnet aesthesiometer), and in vivo confocal microscopy (IVCM, HRT II-RCM) testing. ELISA of tear cytokines (IL1a, TNFa, IL6, MMP 9) and neuropeptides (CGRP, NPFF, VIP, Sub P, NGF) were compared between groups.
RESULTS: Symptomatic VDT users had more years of VDT use (P = 0.0002), reduced corneal sensitivity (P = 0.02), lower Schirmer I (P < 0.0001), lower blink rate (P < 0.0001), and more partial glands (P < 0.001) than asymptomatic users. The daily hours of VDT use (6.4 vs. 6.2), tear osmolarity, immature and mature dendritic cell densities, and IVCM parameters were similar across the two groups. A weak negative correlation of corneal sensitivity was noted with OSDI (P = 0.03) and blink rate (P = 0.037). Mature dendritic cell density had a positive correlation (P = 0.009) with corneal sensitivity. Symptomatic users showed reduced NGF and elevated MMP-9 and IL-1α compared to asymptomatic VDT users.
CONCLUSION: Symptomatic VDT users have reduced mechanical corneal sensitivity without morphological changes in the sub-basal corneal nerve structure. Reduced NGF and elevated tear IL1a and MMP-9 in symptomatic VDT users indicate ocular surface inflammation in VDT-associated dry eye disease.
METHODS: A cross-sectional, single-masked study divided VDT users into symptomatic (n = 51; ocular surface disease index (OSDI) > 13, tear osmolarity, noninvasive tear break-up time (NIBUT) < 10 s, and positive corneal staining) and asymptomatic groups (n = 21, OSDI ≤ 13, NIBUT > 10 s). Participants underwent detailed tear film examination (Oculus keratograph 5M), blink rate, corneal sensitivity (Cochet-Bonnet aesthesiometer), and in vivo confocal microscopy (IVCM, HRT II-RCM) testing. ELISA of tear cytokines (IL1a, TNFa, IL6, MMP 9) and neuropeptides (CGRP, NPFF, VIP, Sub P, NGF) were compared between groups.
RESULTS: Symptomatic VDT users had more years of VDT use (P = 0.0002), reduced corneal sensitivity (P = 0.02), lower Schirmer I (P < 0.0001), lower blink rate (P < 0.0001), and more partial glands (P < 0.001) than asymptomatic users. The daily hours of VDT use (6.4 vs. 6.2), tear osmolarity, immature and mature dendritic cell densities, and IVCM parameters were similar across the two groups. A weak negative correlation of corneal sensitivity was noted with OSDI (P = 0.03) and blink rate (P = 0.037). Mature dendritic cell density had a positive correlation (P = 0.009) with corneal sensitivity. Symptomatic users showed reduced NGF and elevated MMP-9 and IL-1α compared to asymptomatic VDT users.
CONCLUSION: Symptomatic VDT users have reduced mechanical corneal sensitivity without morphological changes in the sub-basal corneal nerve structure. Reduced NGF and elevated tear IL1a and MMP-9 in symptomatic VDT users indicate ocular surface inflammation in VDT-associated dry eye disease.