A Yale Dermatology perspective on cutaneous T cell lymphoma: Historic reflection to emerging therapies.

Cutaneous T cell lymphoma (CTCL) is a form of non-Hodgkin lymphoma that can involve the skin, along with lymph nodes and blood. The two most common subtypes of CTCL are mycosis fungoides and Sézary syndrome. Since the initial description of mycosis fungoides by Dr Jean-Louis Alibert in 1806, there have been significant advances in our understanding of the pathogenesis of CTCL, its diverse clinical and histologic variants, and the evolving treatment landscape. One major contributor to this story has been Dr Irwin M. Braverman, former vice chair of Dermatology at the Yale School of Medicine. Herein, we provide tribute to his discoveries, teaching, mentorship, and clinical care that have influenced our insights into CTCL and emerging treatments for this challenging malignancy.