Internal medicine (Tokyo, Japan) · 2022
Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Murakami Hiroyuki, Makita Masanori, Ishikawa Tatsunori, Yoshioka Takanori, Nagakita Keina, Shinno Yoko, Yoshino Tadashi, Maeda Yoshinobu, Sunami Kazutaka
Аннотация
A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.