Open veterinary journal · 2026
Perioperative analgesia and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy.
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Hernández-Avalos Ismael, Ziaei-Darounkolaei Navid, Crosignani-Outeda Nadia, Sánchez-Aparicio Pedro, García-Peralta Alejandra, Casas-Alvarado Alejandro, Arvizu-Venegas María Del Rosario, Miranda-Cortés Agatha Elisa
Аннотация
BACKGROUND: Perioperative nociception and pain are among the most frequent signs observed following animal surgical procedures. Proper management of perioperative pain is essential for the well-being of animals and the stability of physiological, hemodynamic, biochemical, and behavioral parameters.
AIM: This study aimed to evaluate the analgesic efficacy and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy (OVH) by assessing liver and kidney function-related serum and blood parameters.
METHODS: 30 healthy dogs of different breeds were randomly divided into two groups. G1 (n = 15) received dexketoprofen at 1 mg kg⁻¹ PO before surgery, and every 24 hours for 48 hours; and G2 (n = 15) was premedicated with meloxicam at 0.2 mg kg-1 IV, which was reduced to 0.1 mg kg-1 every 24 hours for 48 hours. HR, respiratory rate, non-invasive blood pressure, esophageal temperature, pulse oximetry (SpO2), and end-tidal CO2were evaluated at the beginning of anesthesia (EBASAL), placement of Backhaus clamp (EPINZ), skin incision and abdominal cavity approach (EINC), ligation and resection of the right ovarian pedicle (EOvD) and left ovarian pedicle (EOvI), ligation and resection of the uterus (EUT), muscle fascia closure (EMUSC), and skin suturing (ESUT). Postoperative analgesia was assessed using the Dynamic Interactive Visual Analog Scale, University of Melbourne Pain Scale, and Glasgow Composite Measurement Pain Scale-Short Form at 1, 2, 4, 6, 8, 12, 24, 36, and 48 hours. Blood and biochemical variables were assessed during EBASAL and at 48 hours.
RESULTS: G1 showed hemodynamic reactivity in systolic blood pressure to surgical manipulation of EOvD and EOvI (p = 0.034), as well as in mean arterial pressure and diastolic blood pressure during EOvI (p = 0.012 and p = 0.024, respectively), compared to EBASAL. The esophageal temperature decreased progressively in G1 (p = 0.006) and G2 (p = 0.003). Postoperative pain scores decreased significantly over time in both groups, with no significant differences between them (p = 0.999). Blood count and chemistry values in both groups showed no changes indicative of hematological, hepatic, or renal toxicity.
CONCLUSION: Dexketoprofen offers effective pain relief with short-term (48 hours) clinical safety similar to that of meloxicam in dogs undergoing OVH, highlighting its potential as a dependable option for multimodal pain management during elective surgical procedures.
AIM: This study aimed to evaluate the analgesic efficacy and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy (OVH) by assessing liver and kidney function-related serum and blood parameters.
METHODS: 30 healthy dogs of different breeds were randomly divided into two groups. G1 (n = 15) received dexketoprofen at 1 mg kg⁻¹ PO before surgery, and every 24 hours for 48 hours; and G2 (n = 15) was premedicated with meloxicam at 0.2 mg kg-1 IV, which was reduced to 0.1 mg kg-1 every 24 hours for 48 hours. HR, respiratory rate, non-invasive blood pressure, esophageal temperature, pulse oximetry (SpO2), and end-tidal CO2were evaluated at the beginning of anesthesia (EBASAL), placement of Backhaus clamp (EPINZ), skin incision and abdominal cavity approach (EINC), ligation and resection of the right ovarian pedicle (EOvD) and left ovarian pedicle (EOvI), ligation and resection of the uterus (EUT), muscle fascia closure (EMUSC), and skin suturing (ESUT). Postoperative analgesia was assessed using the Dynamic Interactive Visual Analog Scale, University of Melbourne Pain Scale, and Glasgow Composite Measurement Pain Scale-Short Form at 1, 2, 4, 6, 8, 12, 24, 36, and 48 hours. Blood and biochemical variables were assessed during EBASAL and at 48 hours.
RESULTS: G1 showed hemodynamic reactivity in systolic blood pressure to surgical manipulation of EOvD and EOvI (p = 0.034), as well as in mean arterial pressure and diastolic blood pressure during EOvI (p = 0.012 and p = 0.024, respectively), compared to EBASAL. The esophageal temperature decreased progressively in G1 (p = 0.006) and G2 (p = 0.003). Postoperative pain scores decreased significantly over time in both groups, with no significant differences between them (p = 0.999). Blood count and chemistry values in both groups showed no changes indicative of hematological, hepatic, or renal toxicity.
CONCLUSION: Dexketoprofen offers effective pain relief with short-term (48 hours) clinical safety similar to that of meloxicam in dogs undergoing OVH, highlighting its potential as a dependable option for multimodal pain management during elective surgical procedures.