Genes, chromosomes & cancer · 2025
MicroRNA Expression in High-Grade B-Cell Lymphoma With 11q Aberration.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Di Stefano Gioia, Fischer Anja, Chteinberg Emil, Bens Susanne, Wagener Rabea, Abramov Dmitriy, Adam Patrick, Bernhart Stephan H, Borkhardt Arndt, Burkhardt Birgit, Del-Val Coral, Frühwald Michael C, Guazzo Raffaella, Hoell Jessica I, Hummel Michael, Horn Heike, Klapper Wolfram, Krugmann Jens, Kurz Katrin S, Lazzi Stefano, Louissaint Abner Jr, Mottok Anja, Oschlies Ilske, Santi Raffaella, Schafernak Kristian, Staiger Annette M, Zhang Yanming, Rosenwald Andreas, Trümper Lorenz, Leoncini Lorenzo, Ott German, Siebert Reiner
Аннотация
Mature aggressive B-cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large B-cell lymphoma (DLBCL), show variations in microRNA (miRNA) expression. The entity of High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) shares several biological features with both BL and DLBCL but data on its miRNA expression profile are yet scarce. Hence, this study aims to analyze the potential differences in miRNA expression of HGBCL-11q compared to BL and DLBCL. We evaluated the expression profiles of 2083 miRNAs in 25 HGCBL-11q, 7 BL, 131 DLBCL, and tonsils using the HTG EdgeSeq miRNA whole transcriptome assay. Uniform manifold approximation and projection (UMAP) and differential gene expression analyses based on DESeq2 were carried out. UMAP analysis of miRNA expression did not reveal distinct groups among the studied lymphomas. However, differential gene expression investigations detected sets of overexpressed miRNAs in HGBCL-11q when compared to BL (miR-9-3p, miR-9-5p, miR-3919, miR-129-1-3p, miR-129-2-3p, miR-331-3p, miR-196b-5p, and miR-28-5p) and DLBCL (miR-3919, miR-1290, miR-4538, and miR-4791), respectively. Notably, miR-3919 showed heterogeneous but significantly higher expression (p-value < 0.001) in HGBCL-11q than in both, BL and DLBCL. We identified a group of differentially expressed miRNAs between HGBCL-11q vs. BL and DLBCL, with miR-3919 as the most commonly and recurrently overexpressed miRNA in HGBCL-11q.