The Journal of pharmacy and pharmacology · 2026
Uterine relaxant effects of Ageratum conyzoides essential oil: influence of hormonal status and calcium modulation.
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Viana Matheus, de Castro Oliveira Júlia Assunção, Bertolucci Suzan Kelly Vilela, Monteforte Priscila Totarelli
Аннотация
OBJECTIVE: We aim to evaluate the influence of A. conyzoides essential oil on uterine contractility, considering hormonal status and potential mechanisms of action.
METHODS: Uterine strips from mice at different estrous stages or after ovariectomy were mounted in an organ bath, and contractile responses were evoked by potassium chloride (KCl, 80 mM) following pre-incubation with increasing concentrations of the essential oil, in the presence or absence of nifedipine, a calcium channel blocker.
KEY FINDINGS: The oil significantly reduced both phasic and tonic components of KCl-induced contractions (P < .01), demonstrating marked relaxant activity. These effects were consistent across estrous cycle stages but were more pronounced in ovariectomized mice. Nifedipine failed to block the oil's inhibitory action, although a potentiation was observed in the tonic phase during estrus (pIC50; -4671 vs -5734; P < .01).
CONCLUSION: A. conyzoides essential oil modulates uterine contractility partly through calcium-independent pathways. This mechanism potentially involves broader smooth muscle signaling mechanisms. The study showcases the therapeutic potential of A. conyzoides in managing uterine hyperactivity and related reproductive disorders.
METHODS: Uterine strips from mice at different estrous stages or after ovariectomy were mounted in an organ bath, and contractile responses were evoked by potassium chloride (KCl, 80 mM) following pre-incubation with increasing concentrations of the essential oil, in the presence or absence of nifedipine, a calcium channel blocker.
KEY FINDINGS: The oil significantly reduced both phasic and tonic components of KCl-induced contractions (P < .01), demonstrating marked relaxant activity. These effects were consistent across estrous cycle stages but were more pronounced in ovariectomized mice. Nifedipine failed to block the oil's inhibitory action, although a potentiation was observed in the tonic phase during estrus (pIC50; -4671 vs -5734; P < .01).
CONCLUSION: A. conyzoides essential oil modulates uterine contractility partly through calcium-independent pathways. This mechanism potentially involves broader smooth muscle signaling mechanisms. The study showcases the therapeutic potential of A. conyzoides in managing uterine hyperactivity and related reproductive disorders.