Ticks and tick-borne diseases · 2019
Genetic diversity of Kemerovo virus and phylogenetic relationships within the Great Island virus genetic group.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Safonova Marina V, Gmyl Anatoly P, Lukashev Alexander N, Speranskaya Anna S, Neverov Alexey D, Fedonin Gennady G, Pimkina Ekaterina V, Matsvay Alina D, Khafizov Kamil F, Karganova Galina G, Kozlovskaya Lubov I, Valdokhina Anna V, Bulanenko Victoria P, Dedkov Vladimir G
Аннотация
Kemerovo virus (KEMV) is a member of the Great Island virus genetic group, belonging to the tick-borne arboviruses of the genus Orbivirus within the family Reoviridae. Nine strains of KEMV, which were isolated from various locations in Russia, were sequenced by high-throughput sequencing to study their intraspecific diversity and the interspecific relationships of viruses within the Great Island genetic group. For the first time, multiple reassortment within KEMV was reliably demonstrated. Different types of independently emerged alternative reading frames in segment 9 and heterogeneity of the viral population in one of the KEMV strains were found. The hypothesis of the role of an alternative open reading frame (ORF) in segment 9 in KEMV cellular tropism was not confirmed in this study.