Association of drug allergy history with Helicobacter pylori infection, duodenal eosinophil and mast cell counts in dyspeptic patients.

This study aimed to evaluate the relationship between Helicobacter pylori infection and duodenal eosinophil-mast cell counts in dyspeptic patients with a history of drug allergy compared to those without such a history. A total of 88 dyspeptic patients with a history of drug allergy and 88 dyspeptic patients without a history of drug allergy (control group), who presented to our internal medicine and gastroenterology clinics, were included in the study. The demographic characteristics, laboratory findings, gastric-duodenal endoscopic findings and biopsy samples obtained via upper gastrointestinal endoscopy were retrospectively compared between the 2 groups. Statistical analysis was performed on the demographic, laboratory, endoscopic and histopathological data of both groups. There was no statistically significant difference between the groups in terms of age and gender parameters (P > .05). However, lymphocyte levels were found to be significantly higher in the group with a history of drug allergy compared to the control group (P = .035 and P = .018, respectively). The presence of H pylori infection, gastric atrophy, and duodenal eosinophil-mast cell counts were significantly higher in the drug allergy group compared to the control group (P < .05). No statistically significant differences were found between the groups in terms of intestinal metaplasia, gastric dysplasia, gastric edema/hyperemia, and duodenal edema/hyperemia (P > .05). The history of drug allergy should be considered in the management of dyspeptic patients. Further large-scale, multicenter, randomized controlled studies are warranted in this area.