Head & neck · 2026
Lateral Cervical Ectopic Thyroid: A Seven-Step Diagnostic Algorithm and Dual-Axis Treatment Strategy Derived From Case Analysis and Literature Review.
СтатьяКлинический случайСистематический обзорНазвание и аннотация: Перевод в очереди
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Huang Shuguang, Wang Ling, Chen Dejie, Zhang Lichuang, Yuan Lebin, Liu Qianrong
Аннотация
BACKGROUND: Lateral cervical ectopic thyroid gland (LETG) is rare and often difficult to distinguish from metastatic lymphadenopathy; furthermore, no standardized surgical strategy is available. This study aims to clarify the clinical features of and establish an optimized management framework for this anomaly.
METHODS: We present one benign LETG case and one malignant LETG case and performed a systematic literature review (2000-2025), yielding a pooled analysis of 69 cases.
RESULTS: The analysis revealed that a definitive pre- or intra-operative diagnosis was pivotal. Malignant pathology in both the lateral neck lesion and the orthotopic thyroid gland predicted multiple surgeries (41.7%, p = 0.007; 39%, p = 0.038). Crucially, the utilization of intraoperative frozen sections was decisive, as all patients who underwent this approach avoided a second operation.
CONCLUSIONS: LETG management necessitates a systematic approach. Our proposed "Seven-Step Diagnostic Algorithm" and "Dual-Axis Treatment Strategy" facilitate precise differentiation, enable a definitive single-stage surgery, minimize reoperations, and guide selective preservation of the orthotopic thyroid.
METHODS: We present one benign LETG case and one malignant LETG case and performed a systematic literature review (2000-2025), yielding a pooled analysis of 69 cases.
RESULTS: The analysis revealed that a definitive pre- or intra-operative diagnosis was pivotal. Malignant pathology in both the lateral neck lesion and the orthotopic thyroid gland predicted multiple surgeries (41.7%, p = 0.007; 39%, p = 0.038). Crucially, the utilization of intraoperative frozen sections was decisive, as all patients who underwent this approach avoided a second operation.
CONCLUSIONS: LETG management necessitates a systematic approach. Our proposed "Seven-Step Diagnostic Algorithm" and "Dual-Axis Treatment Strategy" facilitate precise differentiation, enable a definitive single-stage surgery, minimize reoperations, and guide selective preservation of the orthotopic thyroid.