Esophageal, gastric and duodenal Crohn's disease in the biologic era: Results from a retrospective observational nationwide study of GETECCU.
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История · было → стало
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López-García Alicia, Suárez Ferrer Cristina, Maroto-Martín Carlos, Fernandez-Prada Samuel Juan, Marquina Victoria, Rodríguez Glez G Esther, Mesonero Francisco, Lucendo Alfredo J, Flórez-Díez Pablo, Casanova María José, García-Morales Natalia, Miranda-Bautista José, Vicuña Miren, Font Guillem, Benítez José Manuel, Bernal Lorena, Miquel Oriol, Mínguez Alejandro, Tejedor-Tejada Javier, Pérez-Galindo Pablo, Elosua Alfonso, Lastiri Ernesto Alejandro, Brunet-Mas Eduard, Llaó Jordina, Rodríguez-Lago Iago, Ferreiro-Iglesias Rocío, López Laura, González-Partida Irene, Ortega Silvia Patricia, Monsalve Sara, González-Vivó María, Márquez-Mosquera Lucía, Murciano Gonzalo Francisca, Zabana Yamile, Barreiro-de Acosta Manuel, Young Group of GETECCU
Аннотация
METHODS: We conducted a multicenter retrospective study of adult patients diagnosed with UCD between January 2000 and December 2019, with ≥ 1 year of follow-up. Extensive CD (ECD) was defined as concomitant jejunal, ileal and/or colonic involvement.
RESULTS: One hundred ninety-seven UCD patients were included with a median follow-up of 10.7 years (IQR 5.7-14.2). Only nine (4.6%) had isolated UCD. The inflammatory phenotype predominated, with aphthous ulcers as the main endoscopic lesion (42%). Systemic corticosteroids and thiopurines were the most frequently prescribed therapies after UCD diagnosis. At weeks 14 and 52, response and remission rates for UCD and ECD were similar for all treatments, except higher rates with thiopurines and infliximab in UCD at both time points (p < 0.05). Ten (5.1%) patients shifted phenotype over time (most from inflammatory to stricturing). Two patients developed neoplasia (one gastric MALT lymphoma, one esophageal carcinoma).
CONCLUSIONS: Upper gastrointestinal involvement in adult CD does not appear to alter immunosuppressive therapeutic needs compared with ECD requirements.