Investigative ophthalmology & visual science · 2026
Axial Length Estimation Using Metadata From Swept-Source Optical Coherence Tomography Angiography.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhu Ying, Wagner Sarah L, Zeng Rebecca, Garg Itika, Wang Leiyu, Ding Xinyi, Gumustop Selin S, Nodecker Kayla N, Chen Chong, Ploumi Ioanna, Shah Shivesh H, Vavvas Demetrios G, Patel Nimesh A, Husain Deeba, Miller Joan W, Kim Leo A, Wu David M, Elze Tobias, Miller John B
Аннотация
PURPOSE: The purpose of this study was to explore the possibility of using metadata from optical coherence tomography angiography (OCTA) for axial length (AL) estimation.
METHODS: This retrospective, cross-sectional, observational study included patients with both OCTA imaging and biometry measurements available in a single tertiary medical center from 2019 to 2024. Univariate and multivariate regression analyses were used to build the estimation model of AL using metadata from OCTA.
RESULTS: A total of 198 eyes from 130 patients were included. The average AL was 24.58 mm (interquartile range [IQR] = 22.35-26.81). Univariate regression analysis identified that y_chinrest, z_chinrest, z_lens, and z_motor were all closely related to AL (P < 0.001). The final estimation model derived from multivariate regression analysis was Axial_Length = 24.79611 - 0.25510 × y_chinrest - 0.23443 × z_chinrest - 1.41824 × z_lens + 0.71947 × z_motor. The multiple R-squared value was 0.5586 and adjusted R-squared value was 0.5495. Of the predicted values, 68.7% were within 1 mm of the true AL, and 92.9% were within 2 mm of the true AL. Regression diagnostic plots confirmed assumptions of linearity, homoscedasticity, normality, and no multicollinearity were met. Foveal avascular zone (FAZ) correction with estimated AL showed a reduction in mean absolute error by 31%, from 0.031 mm2 to 0.021 mm2 (P < 0.001).
CONCLUSIONS: The present study demonstrates the possibility of reliable AL estimation using metadata from OCTA.
METHODS: This retrospective, cross-sectional, observational study included patients with both OCTA imaging and biometry measurements available in a single tertiary medical center from 2019 to 2024. Univariate and multivariate regression analyses were used to build the estimation model of AL using metadata from OCTA.
RESULTS: A total of 198 eyes from 130 patients were included. The average AL was 24.58 mm (interquartile range [IQR] = 22.35-26.81). Univariate regression analysis identified that y_chinrest, z_chinrest, z_lens, and z_motor were all closely related to AL (P < 0.001). The final estimation model derived from multivariate regression analysis was Axial_Length = 24.79611 - 0.25510 × y_chinrest - 0.23443 × z_chinrest - 1.41824 × z_lens + 0.71947 × z_motor. The multiple R-squared value was 0.5586 and adjusted R-squared value was 0.5495. Of the predicted values, 68.7% were within 1 mm of the true AL, and 92.9% were within 2 mm of the true AL. Regression diagnostic plots confirmed assumptions of linearity, homoscedasticity, normality, and no multicollinearity were met. Foveal avascular zone (FAZ) correction with estimated AL showed a reduction in mean absolute error by 31%, from 0.031 mm2 to 0.021 mm2 (P < 0.001).
CONCLUSIONS: The present study demonstrates the possibility of reliable AL estimation using metadata from OCTA.