Thrombosis research · 2026
Prevalence and clinical outcomes associated with proximal deep vein thrombosis at hospital admission detected by bedside ultrasound in patients hospitalized in a medical oncology ward: An exploratory prospective study.
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Teigell Muñoz Francisco Javier, García-Ferrón María, Mateos-González María, Bernal Hertfelder Elsa, Sánchez de Torre Ana, Paredes Ruiz Diana, Sevo Spahiu Sara, Bueno Muiño Coralia
Аннотация
BACKGROUND: Venous thromboembolism (VTE) is a frequent and serious complication in patients with cancer. Although lifetime VTE risk is well established, data on the prevalence of proximal deep vein thrombosis (pDVT) at hospital admission are lacking, particularly in medical oncology wards.
OBJECTIVES: To explore the prevalence of pDVT at hospital admission in patients with cancer using systematic bedside ultrasound screening, and to explore associated clinical factors and outcomes.
METHODS: We conducted a prospective, single-center prevalence study including adult patients with solid tumors admitted to a medical oncology ward. Bilateral lower-extremity point-of-care ultrasound using a simplified compression technique was performed within 72 h of admission. Clinical, laboratory, and oncologic variables were recorded. Associations with pDVT were analyzed using univariable and multivariable logistic regression.
RESULTS: A total of 203 patients were included. pDVT was detected in 16 patients (7.9%). The prevalence of pDVT increased with worsening functional status. In multivariable analysis, an ECOG performance status ≥2 and a Khorana score ≥2 were independently associated with pDVT at admission. Patients with pDVT had higher in-hospital mortality (31.3% vs 8.0%) and significantly shorter overall survival (median 36 vs 176 days; p < 0.001). No in-hospital deaths were directly attributable to VTE.
CONCLUSIONS: Bedside ultrasound screening identified a clinically relevant prevalence of previously unrecognized pDVT at hospital admission among patients with cancer. pDVT was associated with poorer functional status, higher thrombotic risk, and worse prognosis. While the clinical benefit of routine screening remains uncertain, further studies are needed before screening strategies can be recommended in this setting.
OBJECTIVES: To explore the prevalence of pDVT at hospital admission in patients with cancer using systematic bedside ultrasound screening, and to explore associated clinical factors and outcomes.
METHODS: We conducted a prospective, single-center prevalence study including adult patients with solid tumors admitted to a medical oncology ward. Bilateral lower-extremity point-of-care ultrasound using a simplified compression technique was performed within 72 h of admission. Clinical, laboratory, and oncologic variables were recorded. Associations with pDVT were analyzed using univariable and multivariable logistic regression.
RESULTS: A total of 203 patients were included. pDVT was detected in 16 patients (7.9%). The prevalence of pDVT increased with worsening functional status. In multivariable analysis, an ECOG performance status ≥2 and a Khorana score ≥2 were independently associated with pDVT at admission. Patients with pDVT had higher in-hospital mortality (31.3% vs 8.0%) and significantly shorter overall survival (median 36 vs 176 days; p < 0.001). No in-hospital deaths were directly attributable to VTE.
CONCLUSIONS: Bedside ultrasound screening identified a clinically relevant prevalence of previously unrecognized pDVT at hospital admission among patients with cancer. pDVT was associated with poorer functional status, higher thrombotic risk, and worse prognosis. While the clinical benefit of routine screening remains uncertain, further studies are needed before screening strategies can be recommended in this setting.