DEN open · 2026
Clinicopathological Features of Superficial Non-Ampullary Duodenal Epithelial Tumors Involving Brunner's Glands.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Takayama Kazuki, Iwatsubo Taro, Ishida Mitsuaki, Sasaki Shun, Hakoda Akitoshi, Sugawara Noriaki, Ota Kazuhiro, Takeuchi Toshihisa, Kawaguchi Nao, Tomioka Atsushi, Tanaka Ryo, Asakuma Mitsuhiro, Lee Sang-Woong, Higuchi Kazuhide, Hirose Yoshinobu, Nishikawa Hiroki
Аннотация
BACKGROUND AND AIMS: Although Brunner's glands (BGs), located in the submucosa of the duodenum, may be involved by tumor cells of superficial non-ampullary duodenal epithelial tumors (SNADETs), the detailed incidence and histopathological features have not yet been analyzed. This study aimed to clarify the histopathological relationship between SNADETs and BGs.
METHODS: We retrospectively analyzed SNADETs that were resected at a single center between 2006 and 2021. Resected specimens were histologically evaluated to determine the presence and/or involvement of SNADET in BGs. The relationship between clinicopathological features and tumor involvement in BGs was also assessed.
RESULTS: In total, 114 lesions were included. Direct connection with BGs was seen in 52.6% of SNADETs, and submucosal BG involvement was observed in 7.0% (95% confidence interval 3.1%-13.4%) of SNADETs. The presence of submucosal BG involvement was significantly associated with 0-IIc morphology, high-grade dysplasia or carcinoma, and the gastric mucinous phenotype. The presence of either a lesion size 10 mm or greater or 0-IIc morphology demonstrated a sensitivity of 100%, a specificity of 34.9%, and a false negative rate of 0% for predicting submucosal BG involvement. Moreover, non-neoplastic BGs were exposed at the vertical margin in 15.1% of endoscopic resection specimens.
CONCLUSION: SNADETs can have submucosal involvement via BGs, particularly in lesions fulfilling either a size ≥10 mm or a 0-IIc morphology. These pathological findings suggest that vertical resectability may be relevant in their endoscopic management, although further studies are needed to clarify clinical implications.
METHODS: We retrospectively analyzed SNADETs that were resected at a single center between 2006 and 2021. Resected specimens were histologically evaluated to determine the presence and/or involvement of SNADET in BGs. The relationship between clinicopathological features and tumor involvement in BGs was also assessed.
RESULTS: In total, 114 lesions were included. Direct connection with BGs was seen in 52.6% of SNADETs, and submucosal BG involvement was observed in 7.0% (95% confidence interval 3.1%-13.4%) of SNADETs. The presence of submucosal BG involvement was significantly associated with 0-IIc morphology, high-grade dysplasia or carcinoma, and the gastric mucinous phenotype. The presence of either a lesion size 10 mm or greater or 0-IIc morphology demonstrated a sensitivity of 100%, a specificity of 34.9%, and a false negative rate of 0% for predicting submucosal BG involvement. Moreover, non-neoplastic BGs were exposed at the vertical margin in 15.1% of endoscopic resection specimens.
CONCLUSION: SNADETs can have submucosal involvement via BGs, particularly in lesions fulfilling either a size ≥10 mm or a 0-IIc morphology. These pathological findings suggest that vertical resectability may be relevant in their endoscopic management, although further studies are needed to clarify clinical implications.