Oral radiology · 2025
Proposal for a new staging system of Sjögren's syndrome using salivary gland SPECT/CT: comparison with Saxon test, MR sialography, and histopathological examination.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Shirai Ai, Toya Shuji, Okada Yasuo, Ogura Ichiro
Аннотация
OBJECTIVES: Sjögren's syndrome causes dryness of the eyes and mouth due to destruction of glandular tissue. Single-photon emission computed tomography/computed tomography (SPECT/CT) is used to evaluate salivary gland function. This study aimed to quantitatively evaluate the stage of Sjögren's syndrome using SPECT/CT maximum standardized uptake value (SUVmax) by comparing the SUVmax with the Saxon test, magnetic resonance (MR) sialography stage, and histopathological grade.
METHODS: This study was conducted in 29 patients with Sjögren's syndrome who underwent the Saxon test, MR sialography, SPECT/CT, and histopathological examination. We compared the SPECT/CT SUVmax with the Saxon test, MR sialography stage, and histopathological grade to determine the stage of Sjögren's syndrome. We then calculated the cutoff value of SUVmax at pre-stimulation for the parotid glands in the early and late stages of Sjögren's syndrome.
RESULTS: The SUVmax for > 2 g per 2 min by the Saxon test was higher than that for ≤ 2 g per 2 min. The SUVmax for MR sialography stages 0-1 was higher than that for stages 2-4. The SUVmax for histopathological grades 0-2 was higher than that for grades 3-4. The cutoff value for early and late Sjögren's syndrome was 20.55 (sensitivity, 0.85; specificity, 0.67).
CONCLUSIONS: SPECT/CT is a highly suitable modality for quantitatively evaluating the stage of Sjögren's syndrome. Especially, the pre-stimulation SUVmax of the parotid glands serves as a valuable indicator for assessing Sjögren's syndrome stage and predicting prognosis.
METHODS: This study was conducted in 29 patients with Sjögren's syndrome who underwent the Saxon test, MR sialography, SPECT/CT, and histopathological examination. We compared the SPECT/CT SUVmax with the Saxon test, MR sialography stage, and histopathological grade to determine the stage of Sjögren's syndrome. We then calculated the cutoff value of SUVmax at pre-stimulation for the parotid glands in the early and late stages of Sjögren's syndrome.
RESULTS: The SUVmax for > 2 g per 2 min by the Saxon test was higher than that for ≤ 2 g per 2 min. The SUVmax for MR sialography stages 0-1 was higher than that for stages 2-4. The SUVmax for histopathological grades 0-2 was higher than that for grades 3-4. The cutoff value for early and late Sjögren's syndrome was 20.55 (sensitivity, 0.85; specificity, 0.67).
CONCLUSIONS: SPECT/CT is a highly suitable modality for quantitatively evaluating the stage of Sjögren's syndrome. Especially, the pre-stimulation SUVmax of the parotid glands serves as a valuable indicator for assessing Sjögren's syndrome stage and predicting prognosis.