IJU case reports · 2026
Rapidly Progressive Retroperitoneal Dissemination of Plasmacytoid Urothelial Carcinoma Presenting With Multiorgan Obstruction After Radical Cystectomy: A Case Report.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Atsuta Mahito, Uchida Naoki, Kagawa Hirokazu, Tomomasa Naoya, Saito Shun, Takahashi Kazuhiro, Iwatani Kosuke, Sato Shun, Kimura Takahiro, Miki Jun
Аннотация
INTRODUCTION: Plasmacytoid urothelial carcinoma (PUC) is a rare, aggressive subtype of bladder cancer characterized by diffuse infiltrative growth and a propensity for peritoneal and retroperitoneal dissemination.
CASE PRESENTATION: A patient with muscle-invasive bladder cancer (cT3N1M0) was diagnosed with conventional high-grade urothelial carcinoma without subtype histology on transurethral resection. After neoadjuvant gemcitabine-cisplatin chemotherapy, robot-assisted radical cystectomy with intracorporeal neobladder reconstruction was performed. Final pathological examination revealed PUC (pT4aN2). Within weeks after surgery, the patient developed sequential retroperitoneal fluid accumulation, bilateral hydronephrosis, duodenal obstruction, and biliary obstruction, suggesting rapid diffuse retroperitoneal progression. Enfortumab vedotin plus pembrolizumab was initiated; however, the disease progressed aggressively, and the patient died on postoperative day 80.
CONCLUSION: PUC may evade detection on initial TUR and can progress rapidly through diffuse retroperitoneal dissemination even after radical cystectomy. Early postoperative, unexplained multiorgan obstructive findings should raise suspicion of occult progression and prompt timely initiation of systemic therapy.
CASE PRESENTATION: A patient with muscle-invasive bladder cancer (cT3N1M0) was diagnosed with conventional high-grade urothelial carcinoma without subtype histology on transurethral resection. After neoadjuvant gemcitabine-cisplatin chemotherapy, robot-assisted radical cystectomy with intracorporeal neobladder reconstruction was performed. Final pathological examination revealed PUC (pT4aN2). Within weeks after surgery, the patient developed sequential retroperitoneal fluid accumulation, bilateral hydronephrosis, duodenal obstruction, and biliary obstruction, suggesting rapid diffuse retroperitoneal progression. Enfortumab vedotin plus pembrolizumab was initiated; however, the disease progressed aggressively, and the patient died on postoperative day 80.
CONCLUSION: PUC may evade detection on initial TUR and can progress rapidly through diffuse retroperitoneal dissemination even after radical cystectomy. Early postoperative, unexplained multiorgan obstructive findings should raise suspicion of occult progression and prompt timely initiation of systemic therapy.