Journal of surgical oncology · 2018
Specific prognostic factors in hepatitis B virus-related and non-hepatitis B virus-related intrahepatic cholangiocarcinoma after macroscopic curative resection.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Huang Jianbo, Wang Xiangyu, Zhu Ying, Wang Zheng, Li Jianhua, Xu Da, Wang Shenghao, Li Tian-En, Lu Lu
Аннотация
BACKGROUND: The hepatitis B virus (HBV)-related intrahepatic cholangiocarcinoma (iCCA) was recognized as a unique subtype of iCCA, within particular features in demography, clinicopathology, and genealogy. However, how they predict prognosis, in particular, for HBV- and non-HBV-related iCCA is still unclear.
METHODS: Demographic, clinicopathologic, and genetic features were retrospectively collected and reviewed to determine the specific prognostic factors, precisely predicting the overall survival (OS) in HBV-related (n = 119) and non-HBV-related ( n = 149) iCCA patients, respectively.
RESULTS: In HBV-related iCCA, TP53 mutation, vascular invasion, extrahepatic metastasis, and serum levels of alpha-fetoprotein (AFP) were independent prognostic factors for OS. In non-HBV-related iCCA, RAS/ RAF mutation and lymphatic metastasis independently predicted the OS of patients. Tumor differentiation and serum levels of CA19-9 were significantly associated with OS in both HBV- and non-HBV-related iCCA patients. In a subset analysis, TP53 and RAS/RAF mutations were consistently related to poorer outcome in HBV- and non-HBV-related iCCA, respectively.
CONCLUSIONS: The HBV- and non-HBV-related iCCA have different prognostic factors for the OS.
METHODS: Demographic, clinicopathologic, and genetic features were retrospectively collected and reviewed to determine the specific prognostic factors, precisely predicting the overall survival (OS) in HBV-related (n = 119) and non-HBV-related ( n = 149) iCCA patients, respectively.
RESULTS: In HBV-related iCCA, TP53 mutation, vascular invasion, extrahepatic metastasis, and serum levels of alpha-fetoprotein (AFP) were independent prognostic factors for OS. In non-HBV-related iCCA, RAS/ RAF mutation and lymphatic metastasis independently predicted the OS of patients. Tumor differentiation and serum levels of CA19-9 were significantly associated with OS in both HBV- and non-HBV-related iCCA patients. In a subset analysis, TP53 and RAS/RAF mutations were consistently related to poorer outcome in HBV- and non-HBV-related iCCA, respectively.
CONCLUSIONS: The HBV- and non-HBV-related iCCA have different prognostic factors for the OS.
Предметные рубрики MeSH
Bile Duct NeoplasmsBiomarkers, TumorCholangiocarcinomaFemaleFollow-Up StudiesHepatectomyHepatitis BHepatitis B Surface AntigensHepatitis B virusHumansLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedMutationNeoplasm InvasivenessPrognosisRetrospective StudiesRisk FactorsSurvival RateTumor Suppressor Protein p53alpha-Fetoproteinsraf Kinasesras Proteins