Correlation between traditional Chinese medicine syndromes of gastro oesophageal reflux disease and high-resolution esophageal manometry findings a cross-sectional study.

Background

This multicentre study examined the association between TCM syndromes and HRM parameters in GERD patients.

Methods

GERD patients were classified into seven syndromes and assessed for LESP, LESL, IRP, DL, DCI, IEM, and fragmented peristalsis.

Results

HRM parameters differed significantly among TCM syndromes (p < 0.01). Liver-Stomach Depression Heat (28.3%, 128/452) and Gallbladder Heat Attacking Stomach (12.4%, 56/452) showed higher LESP (18.5 ± 4.2 and 17.8 ± 3.9 mmHg) and DCI, indicating hypermotility. Middle Deficiency with Qi Counterflow (18.1%, 82/452) and Stomach Yin Deficiency (9.3%, 42/452) showed lower LESP (9.2 ± 2.8 and 8.5 ± 2.5 mmHg) and higher IEM (68.3% and 73.8%), indicating hypomotility. Qi Depression and Phlegm Obstruction (15.0%, 68/452) correlated with fragmented peristalsis (35.3%). Blood Stasis Obstructing the Collaterals (5.8%, 26/452) showed increased IRP (11.2 ± 3.5 mmHg) and abnormal coordination, and Spleen Deficiency with Dampness-Heat was mainly hypomotile.

Conclusion

TCM syndromes in GERD correspond to distinct HRM patterns.