Infectious agents and cancer · 2025
HTLV-1 infection and microRNAs: unraveling the complex crosstalk.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Edalat Fahime, Letafati Arash, Kaghazchi Tanin, Sadeghi Mahdieh, Taheri Ali, Shikki Alireza, Garkani Samira Hossein, Afrozi Mehdi, Norouzi Mehdi, Mozhgani Sayed-Hamidreza
Аннотация
Human T-cell leukemia virus type 1 (HTLV-1) retrovirus that infects millions of individuals worldwide, have caused severe diseases like adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite extensive research efforts, the underlying mechanisms leading to HTLV-1 pathogenesis remain incompletely understood. New research has revealed that microRNAs (miRNAs) play a crucial role in the complex interplay between HTLV-1 infection and host cellular responses. This review highlights the multifaceted interactions between HTLV-1 and miRNAs, encompassing both viral manipulation of cellular miRNA networks and host miRNA-mediated responses. Gaining a comprehensive understanding of the complex interconnection between HTLV-1 infection and miRNAs provides a significant opportunity for discovering innovative therapeutic approaches and creating advanced diagnostic tools aimed in HTLV-1 treatment.