European journal of obstetrics, gynecology, and reproductive biology · 1998
Lymphocytes and dendritic cells in the normal uterine cervix. An immunohistochemical study.
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Poppe W A, Drijkoningen M, Ide P S, Lauweryns J M, Van Assche F A
Аннотация
OBJECTIVE: Assessment of the appearance, distribution and numerical density of immune cell populations in the normal human uterine cervix.
SETTING: University Hospital Gasthuisberg.
SUBJECTS: 29 healthy women undergoing total hysterectomy for non-cervical benign uterine disease.
ANALYSIS: Immunohistochemistry and morphometrical analysis on histological sections containing ectocervix, transformation zone and endocervix, using antibodies against the following antigens: HLA-DR, CD4, CD22, CD1a and CD8.
STATISTICAL ANALYSIS: Wilcoxon rank sum test.
RESULTS: Lymphocytes in the epithelial and stromal compartments are predominantly T-lymphocytes. Intraepithelial T-lymphocyte and Langerhans' cell densities and their distribution are not influenced by the menstrual cycle and are the same in both ectocervix and transformation zone.
CONCLUSION: The wide variation of T lymphocyte subpopulations and Langerhans' cell densities in the normal epithelium of the uterine cervix is stressed. We are the first to present a large and well-defined control series, which is indispensable to study the effect of smoking and other factors on the cervical immune system.
SETTING: University Hospital Gasthuisberg.
SUBJECTS: 29 healthy women undergoing total hysterectomy for non-cervical benign uterine disease.
ANALYSIS: Immunohistochemistry and morphometrical analysis on histological sections containing ectocervix, transformation zone and endocervix, using antibodies against the following antigens: HLA-DR, CD4, CD22, CD1a and CD8.
STATISTICAL ANALYSIS: Wilcoxon rank sum test.
RESULTS: Lymphocytes in the epithelial and stromal compartments are predominantly T-lymphocytes. Intraepithelial T-lymphocyte and Langerhans' cell densities and their distribution are not influenced by the menstrual cycle and are the same in both ectocervix and transformation zone.
CONCLUSION: The wide variation of T lymphocyte subpopulations and Langerhans' cell densities in the normal epithelium of the uterine cervix is stressed. We are the first to present a large and well-defined control series, which is indispensable to study the effect of smoking and other factors on the cervical immune system.