Pediatric blood & cancer · 2025
Human-Centered Design of a Personalized Digital Health Intervention to Improve Oral Chemotherapy Adherence in Adolescents and Young Adults With Hematologic Cancers.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Psihogios Alexandra M, El-Khatib Ayah, Matos Kevin, Rabbi Mashfiqui, Rossoff Jenna, Dinner Shira, Zeng Kristy, Picos Raymundo, Ahmed Annisa, Patel Esha M, Fleisher Linda, Hunger Stephen P, Pai Ahna, Laurenceau Jean-Philippe, Rini Christine, Barakat Lamia P, Schwartz Lisa A, Murphy Susan, Yanez Betina
Аннотация
BACKGROUND: Acute lymphoblastic leukemia/lymphoma therapy includes a maintenance phase involving daily administration of an oral chemotherapy called 6-mercaptopurine (6-MP). Adolescents and young adults (AYAs) exhibit lower 6-MP adherence than younger patients, which increases their relapse risk. However, effective oral chemotherapy adherence interventions for this AYA population are lacking.
OBJECTIVE: This study describes the human-centered design process of co-creating ADAPTS, an app-based just-in-time adaptive intervention for 6-MP adherence in AYAs.
METHODS: Across three design waves with input from AYAs (n = 19) and their caregivers (n = 14), we conducted interviews to co-develop and refine ADAPTS. Qualitative data were coded using conventional content analysis to identify themes that informed app design.
RESULTS: Four design priorities for an oral chemotherapy adherence digital intervention were identified: (i) personalize messages to the contextual factors that fluctuate and impact adherence, such as symptoms and mood; (ii) enhance the persuasiveness of adherence messages by framing them positively (e.g., a focus on maintaining remission rather than preventing a relapse), and including the perspectives of peers in popular social media formats; (iii) include customizable app features and the ability to track personal adherence progress; and (iv) facilitate dyadic adherence communication between AYAs and their caregivers, who are often involved.
CONCLUSIONS: By developing ADAPTS with AYAs and their caregivers, this digital health intervention offers a novel and patient-centric approach to enhancing adherence. The resulting design priorities and human-centered design methods employed have generalizable potential for addressing other AYA cancer health behaviors.
OBJECTIVE: This study describes the human-centered design process of co-creating ADAPTS, an app-based just-in-time adaptive intervention for 6-MP adherence in AYAs.
METHODS: Across three design waves with input from AYAs (n = 19) and their caregivers (n = 14), we conducted interviews to co-develop and refine ADAPTS. Qualitative data were coded using conventional content analysis to identify themes that informed app design.
RESULTS: Four design priorities for an oral chemotherapy adherence digital intervention were identified: (i) personalize messages to the contextual factors that fluctuate and impact adherence, such as symptoms and mood; (ii) enhance the persuasiveness of adherence messages by framing them positively (e.g., a focus on maintaining remission rather than preventing a relapse), and including the perspectives of peers in popular social media formats; (iii) include customizable app features and the ability to track personal adherence progress; and (iv) facilitate dyadic adherence communication between AYAs and their caregivers, who are often involved.
CONCLUSIONS: By developing ADAPTS with AYAs and their caregivers, this digital health intervention offers a novel and patient-centric approach to enhancing adherence. The resulting design priorities and human-centered design methods employed have generalizable potential for addressing other AYA cancer health behaviors.