Fertility and sterility · 1998
Clinical significance of cytogenetic abnormalities in uterine myomas.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Brosens I, Deprest J, Dal Cin P, Van den Berghe H
Аннотация
OBJECTIVE: To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements.
DESIGN: Comparative study of myomas with normal and abnormal karyotype.
SETTING: University hospital.
PATIENTS: Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients.
INTERVENTIONS: Myomectomy or hysterectomy.
MAIN OUTCOME MEASURES: Karyotype analysis and clinical characteristics.
RESULTS: Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%).
CONCLUSIONS: The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.
DESIGN: Comparative study of myomas with normal and abnormal karyotype.
SETTING: University hospital.
PATIENTS: Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients.
INTERVENTIONS: Myomectomy or hysterectomy.
MAIN OUTCOME MEASURES: Karyotype analysis and clinical characteristics.
RESULTS: Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%).
CONCLUSIONS: The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.