Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
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Hughes David J, Duarte-Salles Talita, Hybsier Sandra, Trichopoulou Antonia, Stepien Magdalena, Aleksandrova Krasimira, Overvad Kim, Tjønneland Anne, Olsen Anja, Affret Aurélie, Fagherazzi Guy, Boutron-Ruault Marie-Christine, Katzke Verena, Kaaks Rudolf, Boeing Heiner, Bamia Christina, Lagiou Pagona, Peppa Eleni, Palli Domenico, Krogh Vittorio, Panico Salvatore, Tumino Rosario, Sacerdote Carlotta, Bueno-de-Mesquita Hendrik Bastiaan, Peeters Petra H, Engeset Dagrun, Weiderpass Elisabete, Lasheras Cristina, Agudo Antonio, Sánchez Maria-José, Navarro Carmen, Ardanaz Eva, Dorronsoro Miren, Hemmingsson Oskar, Wareham Nicholas J, Khaw Kay-Tee, Bradbury Kathryn E, Cross Amanda J, Gunter Marc, Riboli Elio, Romieu Isabelle, Schomburg Lutz, Jenab Mazda
Аннотация
OBJECTIVE: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.
DESIGN: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression.
RESULTS: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-μg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ≤ 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63).
CONCLUSION: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.