Indian journal of ophthalmology · 2026
Anterior segment optical coherence tomography-guided assessment of wound healing after cyanoacrylate glue patch for corneal perforations.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Kaur Manpreet, Namdev Vaibhav, Lalu Silpa, Pillai Sarath S, Titiyal Jeewan S
Аннотация
PURPOSE: To evaluate wound healing after cyanoacrylate glue patch (CGP) application in corneal perforations using anterior segment optical coherence tomography (ASOCT).
DESIGN: Prospective interventional case series.
METHODS: Twenty-eight patients with corneal perforations (<4 mm) underwent CGP application. The primary outcome measure was wound healing pattern on ASOCT after CGP application. Secondary outcomes were time to removal of CGP and anatomical success. Follow-up was performed on POD 1 and every 2 weeks till CGP removal.
RESULTS: Three distinct wound healing patterns were observed on ASOCT: Type 1 with corrugated hyper-reflective mass corresponding to CGP with underlying shadowing, Type 2 pattern with ongoing stromal regeneration without continuity with surrounding healthy cornea, and Type 3 with complete stromal regeneration beneath the CGP continuous with surrounding cornea. On POD 1, 100% cases had type 1 pattern. At 2 weeks, 85.7% had type 2; 14.3% had type 1 pattern. At 4 weeks, 35.7% cases had type 3 and 64.3% had type 2 pattern. Five cases underwent early glue removal (type 2 pattern) at 31.8 ± 2.5 days because of CGP intolerance; of these, 40% (2/5) developed a leak and required reapplication of CGP. Total 82.1% cases achieved type 3 pattern by 8 weeks. CGP was removed after documentation of type 3 pattern in 82.1% cases at 41.7 ± 9.2 days; no case developed wound leak.
CONCLUSIONS: ASOCT is a useful adjunct to objectively monitor wound healing after CGP and guide regarding optimal timing for its removal, with type 3 pattern correlating with higher anatomical success.
DESIGN: Prospective interventional case series.
METHODS: Twenty-eight patients with corneal perforations (<4 mm) underwent CGP application. The primary outcome measure was wound healing pattern on ASOCT after CGP application. Secondary outcomes were time to removal of CGP and anatomical success. Follow-up was performed on POD 1 and every 2 weeks till CGP removal.
RESULTS: Three distinct wound healing patterns were observed on ASOCT: Type 1 with corrugated hyper-reflective mass corresponding to CGP with underlying shadowing, Type 2 pattern with ongoing stromal regeneration without continuity with surrounding healthy cornea, and Type 3 with complete stromal regeneration beneath the CGP continuous with surrounding cornea. On POD 1, 100% cases had type 1 pattern. At 2 weeks, 85.7% had type 2; 14.3% had type 1 pattern. At 4 weeks, 35.7% cases had type 3 and 64.3% had type 2 pattern. Five cases underwent early glue removal (type 2 pattern) at 31.8 ± 2.5 days because of CGP intolerance; of these, 40% (2/5) developed a leak and required reapplication of CGP. Total 82.1% cases achieved type 3 pattern by 8 weeks. CGP was removed after documentation of type 3 pattern in 82.1% cases at 41.7 ± 9.2 days; no case developed wound leak.
CONCLUSIONS: ASOCT is a useful adjunct to objectively monitor wound healing after CGP and guide regarding optimal timing for its removal, with type 3 pattern correlating with higher anatomical success.