Locally advanced primary urethral carcinoma in an HIV-positive female patient: report of a case successfully managed with definitive concurrent chemoradiotherapy at a referral cancer center in Abidjan.

Female Primary urethral carcinoma is a rare malignancy frequently diagnosed at an advanced stage. Surgery, the most common treatment modality, is associated with substantial functional impairment. Here, we present the case of a 45-year-old HIV-positive woman with locally advanced squamous cell carcinoma infiltrating the bladder, vagina, and left obturator muscle, treated with definitive concurrent chemoradiotherapy combining fractionated external beam radiotherapy and weekly cisplatin. The treatment resulted in complete remission, which was sustained after 25 months of follow-up. This case supports the effectiveness of definitive concurrent chemoradiotherapy as an organ-preserving approach for advanced female squamous cell carcinoma of urethra.