Diabetes & metabolic syndrome · 2026
Predictive effect of FT3 levels on normal thyroid function in patients with type 2 diabetic kidney disease: A cross-sectional analysis of inpatients in China.
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Zhong Weili, Yue Jinfeng, Zhang Chunhuo, Niu Shuying, Zhao Yanli, Zhao Shangshuang, Yu Ying, Li Jing, Han Jun
Аннотация
BACKGROUND: Evidence for the relationship between free triiodothyronine (FT3) and diabetic kidney disease (DKD) remains limited. Therefore, the purpose of our study was to evaluate the relationship between FT3 and DKD.
METHODS: From June 2022 to October 2023, 3124 patients with normal thyroid function and who were diagnosed with type 2 diabetes (T2D) were collected continuously and nonselectively in a Chinese hospital. We then used a logistic regression model to explore the relationship between FT3 and the estimated glomerular filtration rate (eGFR). Smooth curve fitting was used to identify the nonlinear relationship between FT3 and the eGFR. Additionally, we also performed a series of subgroup analyses.
RESULTS: After adjusting for the influence of relevant factors, FT3 and the eGFR were positively correlated (2.34; 0.27, 4.41; P = 0.0267). There was also a nonlinear relationship between FT3 and the eGFR. The inflection points of FT3 were 3.47 pmol/L (P = 0.002) and 5.17 pmol/L (P = 0.012).
CONCLUSIONS: When the FT3 concentration is 3.47-5.17 pmol/L, the eGFR is the most stable. This will provide a theoretical basis for prospective studies to clarify whether FT3 will affect the DKD process in the future.
METHODS: From June 2022 to October 2023, 3124 patients with normal thyroid function and who were diagnosed with type 2 diabetes (T2D) were collected continuously and nonselectively in a Chinese hospital. We then used a logistic regression model to explore the relationship between FT3 and the estimated glomerular filtration rate (eGFR). Smooth curve fitting was used to identify the nonlinear relationship between FT3 and the eGFR. Additionally, we also performed a series of subgroup analyses.
RESULTS: After adjusting for the influence of relevant factors, FT3 and the eGFR were positively correlated (2.34; 0.27, 4.41; P = 0.0267). There was also a nonlinear relationship between FT3 and the eGFR. The inflection points of FT3 were 3.47 pmol/L (P = 0.002) and 5.17 pmol/L (P = 0.012).
CONCLUSIONS: When the FT3 concentration is 3.47-5.17 pmol/L, the eGFR is the most stable. This will provide a theoretical basis for prospective studies to clarify whether FT3 will affect the DKD process in the future.