Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kaptan Merve, Wang Yiyu, de Boer Augustijn, Goyal Ananya, Holmes Skylar, Ozkan Kerem, Bédard Sandrine, Indriolo Teresa, Law Christine S W, Pfyffer Dario, Fundaun Joel, Berhe Estifanos, Gold Garry E, Chaudhari Akshay, Anoosha Pai S, Gatti Anthony A, Kogan Feliks, Hargreaves Brian A, Delp Scott L, Ratliff John, Hu Serena, Veeravagu Anand, Desai Atman, Tharin Suzanne, Alamin Todd, Smith Andrew C, McKay Marnee J, Kim Brian, Walsh Robert, Schielke Alec, Dennis Dean, Decker Johannes, De Leener Benjamin, Cohen-Adad Julien, Smith Zachary A, Muhammad Fauziyya, Elliott James M, Marquand Andre F, Mackey Sean, Wesselink Evert Onno, Weber Kenneth A
Аннотация
METHODS: UK Biobank participants who underwent whole-body MRI from 2006 to 2010 were included in this retrospective cross-sectional study. The MuscleMap Toolbox quantified volume and intramuscular fat (IMF) in 42 muscles of the abdomen, pelvis, and thigh. Normative models trained on a no pain group generated muscle-specific deviations from normal (i.e., Z-scores) for single- and multi-site chronic and acute pain.
RESULTS: Of 17,843 participants, the primary site-specific analysis included 9,704 no pain, 885 single-site chronic back pain (CBP), 438 single-site chronic hip pain (CHP), and 1,315 single-site chronic knee pain (CKP) participants (n=12,342; mean age 63.7±7.5 years; 52.7% female). Additional analyses included single-site chronic neck/shoulder pain, acute pain, and multi-site chronic pain groups. In CBP, deviations were localized to abdominal muscles, with decreased volume in 6/8 and increased IMF in 6/8. In CHP, deviations were broad, with decreased volume in 3/8 of the abdominal and 14/26 of the thigh muscles, and increased IMF in 6/8 of the abdominal, 5/8 of the pelvic, and 4/26 of the thigh muscles. In CKP, deviations were localized to thigh muscles, with decreased volume in 8/26 and increased IMF in 6/26. Acute pain groups showed no significant differences except for decreased volume in one thigh muscle in acute knee pain. With each additional chronic pain site, volume decreased (β=-.078;IQR:-0.100-0.051), and IMF increased (β=.085;IQR:0.066-0.101). Combined Z-scores classified chronic pain groups better than chance (accuracy: 48.6%;p<.001), but not acute pain groups (accuracy: 39.0%;p=.20).
CONCLUSIONS: Whole-body MRI combined with AI-driven muscle segmentation and normative modeling revealed site-specific patterns of muscle health in single-site chronic pain.