Journal of veterinary internal medicine · 2025
Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Geiger Rachel, Mankin Joe, Volk Holger A, de Decker Steven, van Asselt Nate, Randhawa Karanbir, Ehling Tara, Maitz Charles A, Naramor Ada, Coates Joan R, Stalin Catherine, Johnstone Lauren, Morris Joanna, Plessas Ioannis N, Forward Alexander, Garosi Laurent, Scarpante Elena, Cherubini Giunio, Harcourt-Brown Tom, Carrera-Justiz Sheila, Gutti Jishnu Rao, Takada Marilia, White Joel, Nagata Koichi, Kent Marc, Barber Renee, Ito Daisuke, Nakayama Tomohiro, Oshima Ayaka, Sekigucki Naoki, Smith-Oskrochi Lauren, Jeffery Nick
Аннотация
BACKGROUND: The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown.
OBJECTIVES: To compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy.
ANIMALS: Two hundred eighty-five companion dogs with suspected intracranial meningiomas presenting to 11 specialty clinics in three countries.
METHODS: Parallel cohort comparison study on retrospective data. Dogs diagnosed with intracranial meningioma by board-certified veterinary neurologists or radiologists and treated by radiotherapy or surgery were identified through medical record searches and presenting and survival data extracted. Lesion site was classified as rostro- or caudotentorial and size was measured on contrast magnetic resonance images. Outcome was all-cause death. Analysis of survival by Cox proportional hazards, including selection for optimal multivariable model using lasso, counterfactual modeling including variables associated with treatment allocation and survival.
RESULTS: One hundred sixty-eight dogs received radiotherapy and 117 received surgery. All analyses indicated reduced survival associated with surgery compared to radiotherapy. There was a median survival after surgery of 297 (IQR: 99-768) days compared with 696 (IQR: 368-999) for dogs treated by radiation, associated with a univariable hazard ratio of 1.802 (95% CI: 1.357-2.394). Counterfactual modeling estimated a mean survival of 480 (95% CI: 395-564) days after surgery and 673 (95% CI: 565-782) days after radiotherapy, representing a decrease in survival of 29%. Location and size of the lesion were not associated with survival duration.
CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with suspected intracranial meningioma have substantially superior survival after radiotherapy compared to surgery.
OBJECTIVES: To compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy.
ANIMALS: Two hundred eighty-five companion dogs with suspected intracranial meningiomas presenting to 11 specialty clinics in three countries.
METHODS: Parallel cohort comparison study on retrospective data. Dogs diagnosed with intracranial meningioma by board-certified veterinary neurologists or radiologists and treated by radiotherapy or surgery were identified through medical record searches and presenting and survival data extracted. Lesion site was classified as rostro- or caudotentorial and size was measured on contrast magnetic resonance images. Outcome was all-cause death. Analysis of survival by Cox proportional hazards, including selection for optimal multivariable model using lasso, counterfactual modeling including variables associated with treatment allocation and survival.
RESULTS: One hundred sixty-eight dogs received radiotherapy and 117 received surgery. All analyses indicated reduced survival associated with surgery compared to radiotherapy. There was a median survival after surgery of 297 (IQR: 99-768) days compared with 696 (IQR: 368-999) for dogs treated by radiation, associated with a univariable hazard ratio of 1.802 (95% CI: 1.357-2.394). Counterfactual modeling estimated a mean survival of 480 (95% CI: 395-564) days after surgery and 673 (95% CI: 565-782) days after radiotherapy, representing a decrease in survival of 29%. Location and size of the lesion were not associated with survival duration.
CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with suspected intracranial meningioma have substantially superior survival after radiotherapy compared to surgery.