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Journal of inflammation research · 2025

The Prognostic Value of Complete Blood Count-Derived Inflammatory Indicators for All-Cause Mortality in Type 2 Diabetes Mellitus: A Retrospective Cohort Study.

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Dhakal Binod, Akhtar Othman S, Fandrei David, Jensen Alexandria, Banerjee Rahul, Pan Darren, Richard Shambavi, Friend Reed, Rees Matthew, Costello Patrick, Vazquez Martinez Mariola, Pasvolsky Oren, Wagner Charlotte, Davis James A, Castaneda Puglianini Omar, Reshef Ran, Afrough Aimaz, Dima Danai, Bhutani Manisha, Nadeem Omar, Parrondo Ricardo, Freeman Ciara, Mikkilineni Lekha, Raza Shahzad, Anderson Larry D, Kapoor Prashant, Hosoya Hitomi, Chhabra Saurabh, Grajales-Cruz Ariel, Gaballa Mahmoud, Midha Shonali, Alsina Melissa, Sborov Douglas, Patel Krina, Lin Yi, Ferreri Christopher, Gagelmann Nico, Kumar Anupama, Hansen Doris, Cowan Andrew, Costa Luciano J, Merz Maximilian, Sidana Surbhi

Аннотация

INTRODUCTION: Ureteroscopic procedures pose a splash hazard to urologists from irrigant contaminated with urine, blood, or caustic substances, risking health and vision. While ureteroscopic adapters aim to minimize fluid leakage, their efficacy remains unstandardized, with high-pressure irrigation potentially generating hazardous spray. This study aimed to evaluate the potential for hazardous leak of various ureteroscopic adapters.

METHODS: Six different ureteroscopic adapters were assessed while performing ureteroscopy through a tissue-realistic kidney and ureter model at various levels of pressurized saline generated via a pressure bag and a single-action pumping system (SAPS) with and without a stone basket in the working channel. Leaking was classified as a drip (non-projectile leakage), a spray (small-volume projectile leak), or a splash (large-volume projectile leak). Hazardous spray was defined as any projectile leakage. Ultraviolet fluorescent stain was instilled in the irrigation and utilized to measure the maximal spray distance from the surgeon.

RESULTS: The Gyrus Adjustable Biopsy Port Seal had the highest potential for splash, including at gravity. Other adapters that exhibited hazardous leakage include the Gyrus Blue Silicone Seal with a basket in place and the Merit Hemostasis Valve while under high pressure using SAPS. Only one valve demonstrated no leak under any simulated circumstances (the Medtronic Piton). The Cook Check-Flo Adapter and Boston Scientific Urolok II demonstrated nonhazardous leakage. In the second arm of the experiment, maximal spray distance using the Gyrus Adjustable Biopsy Port Seal was 14.4 feet.

CONCLUSION: Ureteroscopic adapter leakage can be variable among adapters, and surgeons should be aware of the hazardous potential for exposure.

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

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