Clinical variations and outcomes of central serous chorioretinopathy in Black and White patients: MICRoN report-16.
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Sahoo Niroj Kumar, Hasan Nasiq, Momenaei Bita, Ni Roselind, Garg Sunir, Gregori Giulia, Lupidi Marco, Cao Jessica, Wykoff Charles C, Shah Priya, Singhanetr Panisa, Rossin Elizabeth, Villafuerte-Trisolini Carol, Yiu Glenn, Winter Halit, Gill Manjot K, Coletto Andrea, El Barkani Mohamed, Bousquet Elodie, Desideri Lorenzo Ferro, Hertkorn Felicia, Munk Marion R, Wang Jay, Khurana Rahul N, Ashfaq Yusuf, Kroeger Zachary, Parodi Maurizio Battaglia, Piccoli Gabriele, Vujosevic Stela, Rodríguez-Fernández Carmen Antía, Barquet Luis Arias, Small Kent, Silva Rufino, Lima Luiz H, Fung Adrian T, Wu Lihteh, Chhablani Jay, Macula Society International CSCR Research Network (MICRoN)
Аннотация
METHODS: This retrospective, multicenter study from the MICRoN study group, included Black and White patients with CSCR. Demographic information and multimodal imaging parameters were analyzed and compared in the two groups. Regression models were used to identify factors affecting visual outcomes, anatomical changes, and disease recurrence/persistence.
RESULTS: We included a total of 450 patients (312 males and 138 females), of whom 100 were Black patients, and 350 were White patients. Black patients were significantly older (51.9 versus 48.8 years, p=0.03) but had shorter symptom duration at presentation (1 versus 3 months, p=0.003). They demonstrated worse baseline visual acuity (0.3±0.3 versus 0.2±0.2 logMAR, p<0.001), greater retinal detachment height (157.9 versus 107.5 μm, p=0.002), and more frequent peripapillary retinal pigment epithelium changes (27% versus 9.4%, p<0.001). During a median follow-up of 24 months (IQR 10 to 60 months), White patients experienced significantly higher rates of disease recurrence (35.7% versus 19%, p=0.002), persistent subretinal fluid (13.1% versus 4%, p=0.01), and macular neovascularization development (21.1% versus 4%, p<0.001). Multivariable regression confirmed that Black patients were associated with reduced recurrence risk (OR 0.52, p=0.03).
CONCLUSIONS: Despite presenting with more severe morphological changes and worse initial vision, Black patients demonstrate substantially lower rates of recurrences and sequelae, suggesting biological differences in disease pathophysiology.