Future oncology (London, England) · 2017
S100A6 promotes proliferation of intrahepatic cholangiocarcinoma cells via the activation of the p38/MAPK pathway.
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Zheng Susu, Shen Hujia, Jia Qingan, Jing Chuyu, Lin Jiajia, Zhang Meixia, Zhang Xiaolei, Zhang Boheng, Liu Yinkun
Аннотация
AIM: We explored the expression of S100A6 and its role in intrahepatic cholangiocarcinoma (ICC).
METHODS: The expression of S100A6 in ICC samples was detected by immunohistochemistry. In vitro experiments, we silenced and overexpressed S100A6 to investigate its role in cell functions.
RESULTS: The expression of S100A6 was markedly increased in ICC tissues and cell lines. S100A6 overexpression was an independent risk factor for patients' survival. Silencing S100A6 resulted in a suppression of proliferation and p38/MAPK activity, while overexpressing S100A6 caused a promotion of proliferation and p38/MAPK.
DISCUSSION: S100A6 participated in the proliferation of ICC cells and correlated with a more aggressive behavior of ICC. Conclusion: S100A6 may serve as a novel prognostic marker and a potential therapeutic target for ICC patients.
METHODS: The expression of S100A6 in ICC samples was detected by immunohistochemistry. In vitro experiments, we silenced and overexpressed S100A6 to investigate its role in cell functions.
RESULTS: The expression of S100A6 was markedly increased in ICC tissues and cell lines. S100A6 overexpression was an independent risk factor for patients' survival. Silencing S100A6 resulted in a suppression of proliferation and p38/MAPK activity, while overexpressing S100A6 caused a promotion of proliferation and p38/MAPK.
DISCUSSION: S100A6 participated in the proliferation of ICC cells and correlated with a more aggressive behavior of ICC. Conclusion: S100A6 may serve as a novel prognostic marker and a potential therapeutic target for ICC patients.
Предметные рубрики MeSH
AdultAgedBile Duct NeoplasmsCell Cycle ProteinsCell Line, TumorCell MovementCell ProliferationCholangiocarcinomaFemaleFollow-Up StudiesGene ExpressionHumansLymphatic MetastasisMAP Kinase Signaling SystemMaleMiddle AgedNeoplasm GradingNeoplasm StagingS100 Calcium Binding Protein A6p38 Mitogen-Activated Protein Kinases