Journal of dental sciences · 2025
Characterization of the oral microbiota in zygomatic versus dental implants: Implications for full-mouth rehabilitation.
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Sung Min-Yi, Hsu Po-Chih, Kuo Chan-Yen, Chen Liang-Kun, Tsai Chung-Che, Hsu Yi-Chiung
Аннотация
BACKGROUND/PURPOSE: Dental implants are widely used to restore oral function and esthetics in patients with tooth loss. General zygomatic implants (GZIs) are a valuable alternative for patients with severely atrophic maxillae or post-oncologic defects. However, implant placement can alter the ecological balance of the oral microbiota, potentially influencing peri-implant and sinus-related diseases. Because GZIs often traverse or adjoin the maxillary sinus, their microbial environment may differ from that of general dental implants (GDIs). This study aimed to compare microbiota taxonomy between GZI and GDI sites.
MATERIALS AND METHODS: Generally healthy adults treated with either general zygomatic implants (GZI group) or general dental implants (GDI group) at a teaching hospital dental clinic were recruited. Biofilm samples were collected from implant surfaces under aseptic conditions. Microbial DNA was extracted and analyzed using 16S rRNA gene amplicon sequencing. Taxonomic classification and diversity analyses were performed through bioinformatic pipelines to identify bacterial genera and compare microbial community composition between groups.
RESULTS: Distinct microbial profiles were observed between the GZI and GDI groups. Rothia, Thermus, and Sphingomonas were significantly more abundant in the GZI group, whereas Capnocytophaga and Leptotrichia predominated in the GDI group, reflecting greater richness in the latter. Notably, Rothia species commonly linked to sinus infections were enriched in the GZI group, suggesting sinus-associated microbiome alterations.
CONCLUSION: Implant type significantly influences peri-implant microbiota composition. Zygomatic implants exhibit distinct microbial communities potentially associated with sinus involvement. Further studies are needed to clarify their role in peri-implant and sinus-related pathogenesis.
MATERIALS AND METHODS: Generally healthy adults treated with either general zygomatic implants (GZI group) or general dental implants (GDI group) at a teaching hospital dental clinic were recruited. Biofilm samples were collected from implant surfaces under aseptic conditions. Microbial DNA was extracted and analyzed using 16S rRNA gene amplicon sequencing. Taxonomic classification and diversity analyses were performed through bioinformatic pipelines to identify bacterial genera and compare microbial community composition between groups.
RESULTS: Distinct microbial profiles were observed between the GZI and GDI groups. Rothia, Thermus, and Sphingomonas were significantly more abundant in the GZI group, whereas Capnocytophaga and Leptotrichia predominated in the GDI group, reflecting greater richness in the latter. Notably, Rothia species commonly linked to sinus infections were enriched in the GZI group, suggesting sinus-associated microbiome alterations.
CONCLUSION: Implant type significantly influences peri-implant microbiota composition. Zygomatic implants exhibit distinct microbial communities potentially associated with sinus involvement. Further studies are needed to clarify their role in peri-implant and sinus-related pathogenesis.