Gan to kagaku ryoho. Cancer & chemotherapy · 2023
[A Case of Response to Pembrolizmab in Unresectable MSI-High Transverse Colon Cancer].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Shindo Miki, Kagawa Yoshinori, Nishizawa Yujiro, Inoue Akira, Ozato Yuki, Kumode Akinori, Santo Masumi, Ueda Yuki, Kimura Miho, Fukui Akiko, Miyazaki Yasuhiro, Tomokuni Akira, Motoori Masaaki, Iwase Kazuhiro, Fuzitani Kazumasa
Аннотация
A 80s man was diagnosed circulated type 2 colon cancer at the transverse colon, and pathological findings was adenocarcinoma( por1). Genomic findings were microsatellite instability-high(MSI-H), all RAS wild type and BRAFV600E mutated. Contrast-enhanced CT showed an enlarged lymph nodes(#221, #222, #223, #214)along the middle colic and superior mesenteric artery. Clinical diagnosis was a locally advanced unresectable transverse colon cancer, cT4aN3M1a(LYM), cStage Ⅳa. Drug therapy with pembrolizumab was prescribed. Six months later, contrast-enhanced CT and PET demonstrated remarkable shrinkage of the primary tumor and lymph nodes except 2 peri-colic enlarged lymph nodes. Primary lesion turned almost undetectable, however the biopsy demonstrated residual tumor. Two months later, CT showed that the residual lymph nodes had also disappeared.