BMC nephrology · 2025
Thrombotic microangiopathy associated with mantle cell lymphoma: a case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tonouchi Yuri, Hashimoto Koji, Iwabuchi Ryohei, Sakai Hitoshi, Nimura Takayuki, Yamaka Kosuke, Nishikawa Marina, Yamaguchi Akinori, Sonoda Kosuke, Kamijo Yuji
Аннотация
BACKGROUND: Thrombotic microangiopathy (TMA) is a syndrome characterized by vascular endothelial cell damage, with anemia, thrombocytopenia, and thrombus-related organ damage. Secondary TMA is caused by various factors, including hematological malignancy. Case reports on TMA with mantle cell lymphoma (MCL) are extremely rare. Herein, we report a case of secondary TMA wherein MCL was diagnosed based on the same kidney biopsy specimen and treated with chemotherapy, resulting in improvement in TMA.
CASE PRESENTATION: A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; however, the TMA did not improve. Immunostaining of the kidney biopsy specimen revealed MCL; chemotherapy was initiated, which improved the thrombocytopenia and hemolysis.
CONCLUSIONS: To our best knowledge, this is a very rare case of secondary TMA owing to MCL wherein chemotherapy was effective, suggesting a causal relationship. Kidney biopsy was key to identifying the underlying malignancy.
CASE PRESENTATION: A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; however, the TMA did not improve. Immunostaining of the kidney biopsy specimen revealed MCL; chemotherapy was initiated, which improved the thrombocytopenia and hemolysis.
CONCLUSIONS: To our best knowledge, this is a very rare case of secondary TMA owing to MCL wherein chemotherapy was effective, suggesting a causal relationship. Kidney biopsy was key to identifying the underlying malignancy.