The Journal of infectious diseases · 2025
Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Hall Victoria G, Nguyen Thi H O, Smibert Olivia C, Allen Lilith F, Sullivan Sheena G, Fox Annette, Carolan Louise, Wheatley Adam K, Kent Stephen J, Gilbertson Brad, Lim Chhay, Barr Ian G, Peck Heidi, Fuge-Larsen Paula, Klimevski Emily, Tennakoon Surekha, Saunders Natalie R, Joyce Trish, Whitechurch Ashley, Khot Amit, Anderson Mary Ann, Trubiano Jason A, Worth Leon J, Yong Michelle K, Slavin Monica A, Kedzierska Katherine, Teh Benjamin W
Аннотация
BACKGROUND: There are few in-depth immunogenicity analyses of novel influenza vaccination strategies in high-risk patients with hematological malignancy (HM).
METHODS: Participants receiving treatment for active HM (multiple myeloma [MM], chronic lymphocytic leukemia [CLL], or non-Hodgkin lymphoma [NHL]) in a randomized controlled trial of 2 doses of adjuvanted quadrivalent inactivated influenza vaccine (QIV) versus 2 doses of standard-dose QIV during 2022 were included. Hemagglutination (HA) inhibition assay and HA probe-specific B-cells were compared at baseline and 1, 2, and 6 months after the first vaccine dose (visits 1-4). A subset underwent ex vivo live virus infection of peripheral blood mononuclear cells at visits 1 and 3 with A/H1N1 and A/H3N2 to assess interferon (IFN) γ-producing CD4+ T cells, CD8+ T cells, natural killer cells, CD161+TRAV1-2+ mucosal-associated invariant T (MAIT)-like T cells and γδ T cells.
RESULTS: In total, 62 patients with HM were analyzed (32 in the adjuvanted-dose and 30 in the standard-dose group), 13 (21.0%) with CLL, 24 (38.7%) MM, and 25 (40.3%) with NHL. Participants with MM had higher geometric mean antibody titers (P < .001) and influenza-specific B-cell responses for H1, H3, and B/Victoria at visits 2 and 3 than those with CLL or NHL (P < .05). The total CD19+ B-cell and HA probe-specific B-cell counts were found to significantly predict seroconversion at visits 2 and 3. Overall, with vaccination, there was an increase in the percentage frequency of B/Victoria influenza-specific B-cells (P = .01), IFN-γ-producing CD4+ T cells (P = .01) for A/H1N1 and IFN-γ-producing MAIT-like cells (P = .003) for A/H3N2.
CONCLUSIONS: Influenza strain-specific cellular responses were detectable following vaccination despite expected B-cell depletion in patients receiving active treatment for HM.
CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12622000454774.
METHODS: Participants receiving treatment for active HM (multiple myeloma [MM], chronic lymphocytic leukemia [CLL], or non-Hodgkin lymphoma [NHL]) in a randomized controlled trial of 2 doses of adjuvanted quadrivalent inactivated influenza vaccine (QIV) versus 2 doses of standard-dose QIV during 2022 were included. Hemagglutination (HA) inhibition assay and HA probe-specific B-cells were compared at baseline and 1, 2, and 6 months after the first vaccine dose (visits 1-4). A subset underwent ex vivo live virus infection of peripheral blood mononuclear cells at visits 1 and 3 with A/H1N1 and A/H3N2 to assess interferon (IFN) γ-producing CD4+ T cells, CD8+ T cells, natural killer cells, CD161+TRAV1-2+ mucosal-associated invariant T (MAIT)-like T cells and γδ T cells.
RESULTS: In total, 62 patients with HM were analyzed (32 in the adjuvanted-dose and 30 in the standard-dose group), 13 (21.0%) with CLL, 24 (38.7%) MM, and 25 (40.3%) with NHL. Participants with MM had higher geometric mean antibody titers (P < .001) and influenza-specific B-cell responses for H1, H3, and B/Victoria at visits 2 and 3 than those with CLL or NHL (P < .05). The total CD19+ B-cell and HA probe-specific B-cell counts were found to significantly predict seroconversion at visits 2 and 3. Overall, with vaccination, there was an increase in the percentage frequency of B/Victoria influenza-specific B-cells (P = .01), IFN-γ-producing CD4+ T cells (P = .01) for A/H1N1 and IFN-γ-producing MAIT-like cells (P = .003) for A/H3N2.
CONCLUSIONS: Influenza strain-specific cellular responses were detectable following vaccination despite expected B-cell depletion in patients receiving active treatment for HM.
CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12622000454774.