International journal of radiation oncology, biology, physics · 2006
Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control.
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Akimoto Tetsuo, Nonaka Tetsuo, Kitamoto Yoshizumi, Ishikawa Hitoshi, Ninomiya Hiroshi, Chikamatsu Kazuaki, Furuya Nobuhiko, Hayakawa Kazushige, Mitsuhashi Norio, Nakano Takashi
Аннотация
PURPOSE: The impact of concurrent chemotherapy on the local control in patients with T2N0 laryngeal cancer who receive radiation therapy (RT) was evaluated.
METHODS AND MATERIALS: Sixty-three patients with T2N0 laryngeal cancer who were treated by definitive RT were analyzed. The primary site of the cancer was the glottis in 50 patients, the supraglottis in 9 patients, and the subglottis in 4 patients. Thirty-six patients were treated by RT alone and the remaining 27 patients received concurrent chemoradiotherapy (CRT).
RESULTS: Complete response (CR) was obtained in 92% of the patients who received RT alone and 100% of the patients who received CRT. Voice preservation in the group who received CRT (89%) was significantly higher than that in the group treated by RT alone (61%). The 5-year disease-free survival rates in those who received concurrent CRT was significantly superior to that in the patients who received RT alone, although no significant difference was seen in the cause-specific survival rate between the 2 groups. The multivariate analysis revealed that the treatment method (RT alone vs. CRT) was the most significant risk factor that predicted recurrence after RT.
CONCLUSION: Concurrent CRT had a positive impact on the local control of T2N0 laryngeal cancer.
METHODS AND MATERIALS: Sixty-three patients with T2N0 laryngeal cancer who were treated by definitive RT were analyzed. The primary site of the cancer was the glottis in 50 patients, the supraglottis in 9 patients, and the subglottis in 4 patients. Thirty-six patients were treated by RT alone and the remaining 27 patients received concurrent chemoradiotherapy (CRT).
RESULTS: Complete response (CR) was obtained in 92% of the patients who received RT alone and 100% of the patients who received CRT. Voice preservation in the group who received CRT (89%) was significantly higher than that in the group treated by RT alone (61%). The 5-year disease-free survival rates in those who received concurrent CRT was significantly superior to that in the patients who received RT alone, although no significant difference was seen in the cause-specific survival rate between the 2 groups. The multivariate analysis revealed that the treatment method (RT alone vs. CRT) was the most significant risk factor that predicted recurrence after RT.
CONCLUSION: Concurrent CRT had a positive impact on the local control of T2N0 laryngeal cancer.
Предметные рубрики MeSH
AgedAged, 80 and overAnalysis of VarianceAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellCisplatinCombined Modality TherapyDisease-Free SurvivalDocetaxelFemaleGlottisHumansLaryngeal NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalRadiotherapy DosageRemission InductionRetrospective StudiesSurvival RateTaxoidsVoice Quality