Lysosomal signaling pathways influence heart rhythm, and regulate atrial function.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Akerman Emily, Capel Rebecca A, Rog-Zielinska Eva A, Winbo Annika, Aston Daniel, Falter Florian, Bin Abdul Mu-U-Min Razik, Read Matthew J, Bose Samuel J, Swietach Pawel, Wang Jingyu, Corbett Alexander D, Koschinski Andreas, Calamaio Serena, Melgari Dario, Prevostini Rachele, Rivolta Ilaria, Ayagama Thamali, Jenkin Ifan, Simon Jillian N, Fakuade Funsho E, Pronto Julius R, Sharma Parveen, Melia Charlotte, Song Qianqian, Booth Martin J, Platt Frances M, Lei Ming, Hester Svenja, Fischer Roman, Voigt Niels, Schotten Ulrich, Verheule Sander, Dev Aiswarya, Held Marie, Waring Thomas, Galione Antony, Keller Marco, Bracher Franz, Zaccolo Manuela, Terrar Derek A, Burton Rebecca A B
Аннотация
METHODS AND RESULTS: Pharmacological or genetic ablation of the NAADP pathway inhibits the spontaneous beating rate response to β-adrenergic stimulation in intact SAN. We found intracellular signaling microdomains between lysosomes and neighboring SR or mitochondria in mouse, and goat tissue. The spatial relationship between lysosomes and other Ca2+-handling organelles are altered in goat atrial fibrillation. Furthermore, we demonstrate atrial myocytes produce 3'-5'-cyclic adenosine monophosphate (cAMP) in response to lysosomal signaling, adding a novel trigger for cyclic nucleotide signaling.
CONCLUSIONS: Our findings support the hypothesis that lysosomal Ca2+ signaling contributes to regulation of cardiomyocyte cAMP levels and pacemaker activity.