Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jackson Sarah S, Adami Hans-Olov, Andreotti Gabriella, Beane-Freeman Laura E, Berrington de González Amy, Buring Julie E, Fraser Gary E, Freedman Neal D, Gapstur Susan M, Gierach Gretchen, Giles Graham G, Grodstein Francine, Hartge Patricia, Jenab Mazda, Kirsh Victoria, Knutsen Synnove F, Lan Qing, Larsson Susanna C, Lee I-Min, Lee Mei-Hsuan, Liao Linda M, Milne Roger L, Monroe Kristine R, Neuhouser Marian L, O'Brien Katie M, Petrick Jessica L, Purdue Mark P, Rohan Thomas E, Sandin Sven, Sandler Dale P, Sawada Norie, Shadyab Aladdin H, Simon Tracey G, Sinha Rashmi, Stolzenberg-Solomon Rachael, Tsugane Shoichiro, Weiderpass Elisabete, Wolk Alicja, Yang Hwai-I, Zheng Wei, McGlynn Katherine A, Campbell Peter T, Koshiol Jill
Аннотация
METHODS: We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study.
RESULTS: During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR ≥5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only.
CONCLUSION: We observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography.
LAY SUMMARY: Our findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer and extrahepatic bile duct cancer. We did not see this same association in women from Western countries. Age at menopause was not associated with the risk of any biliary tract cancers.