medRxiv : the preprint server for health sciences · 2026
Preserved Medial Temporal Lobe Flexibility Predicts Memory Generalization Only in the Context of Good Sleep Quality among Older African Americans.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
White Payton, Budak Miray, Moallemian Soodeh, Fausto Bernadette A, Gluck Mark A
Аннотация
OBJECTIVES: Poor sleep quality is a risk factor for Alzheimer's disease (AD). Older African Americans experience disproportionately high rates of sleep disturbance and AD. Medial temporal lobe (MTL) flexibility reflects dynamic neural reorganization and may be a marker of generalization performance. This study examined whether sleep quality moderates the association between MTL flexibility and memory generalization.
METHODS: Fifty older African Americans (MeanAge=69.7±6.21 years; 80% women) underwent rs-fMRI to quantify MTL flexibility, Rutgers Acquired Equivalence Task for memory generalization, and Pittsburgh Sleep Quality Index for sleep quality.
RESULTS: Greater MTL flexibility was associated with better generalization (r=0.367, p=.017). Good sleepers showed higher MTL flexibility (F(1,44)=8.11, ηp2=.156, p=.007) and superior generalization (F(1,46)= 12.33, ηp2=.211, p=.001). Sleep quality significantly moderated the MTL flexibility-generalization relationship (β=-1.519, p=.012).
CONCLUSIONS: Preserved MTL flexibility may confer generalization only in good sleepers, suggesting that sleep disturbance may disrupt the MTL neural resilience among older African Americans.
METHODS: Fifty older African Americans (MeanAge=69.7±6.21 years; 80% women) underwent rs-fMRI to quantify MTL flexibility, Rutgers Acquired Equivalence Task for memory generalization, and Pittsburgh Sleep Quality Index for sleep quality.
RESULTS: Greater MTL flexibility was associated with better generalization (r=0.367, p=.017). Good sleepers showed higher MTL flexibility (F(1,44)=8.11, ηp2=.156, p=.007) and superior generalization (F(1,46)= 12.33, ηp2=.211, p=.001). Sleep quality significantly moderated the MTL flexibility-generalization relationship (β=-1.519, p=.012).
CONCLUSIONS: Preserved MTL flexibility may confer generalization only in good sleepers, suggesting that sleep disturbance may disrupt the MTL neural resilience among older African Americans.